114 INTERNAL SECRETIONS OF THE OVARY 



metabolism of ovariectomized females following injection of 

 oestrin. No effect was observed in castrated males. Fraenkel 

 (212) failed to raise the total metabolism of women by similar 

 treatment. Dickens, Dodds, and Wright (158) have reported an 

 antagonistic action of fat-soluble oestrin to the hypoglycaemic 

 effect of insulin. 



Effect on groivth and activity. Bugbee and Simond (112) state 

 that the injection of oestrin causes a dechne in weight of normal 

 and gonadectomized animals of both sexes. Brouha and 

 Simonnet (90) and Allen and Doisy (24), however, found no 

 effect on the growth of the immature animal. 



Slonaker (566) and Wang, Richter and Guttemacher (630) 

 have shown that the spontaneous activity of rats undergoes 

 cyclic variation in correlation with the cestrous cycle, the 

 maximum activity occurring at oestrus. This increased activity 

 stops after ovariectomy, but can be brought about in the 

 ovariectomized animal by the injection of oestrin (m). Con- 

 tinuous injection leads to continuous increased activity. 



