154 INTERNAL SECRETIONS OF THE OVARY 



(500). The ovum itself then shows atrophic changes, such as 

 fragmentation of the nucleus and general shrinkage. The con- 

 tinuing hypertrophy of the follicular epithelium gradually 

 closes the cavity of the follicle, until the latter becomes solid. 

 Mitoses are not observed during this process and the increase in 



Fig. 51. — Ovary of adult Mouse injected with Sodium 

 hydroxide extract of anterior pituitary body. 



Large numbers of atretic corpora lutea are present, and few- 

 follicles. 



the amount of tissue can be accounted for solely by the growth, 

 mainly cytoplasmic, of the individual cells. Allowing for the 

 restricted space and the presence of liquor folliculi and the ovum, 

 the process appears to be analogous with that normally occurring 

 after ovulation. The corpora lutea atretica thus formed are 

 crowded closely together, but do not become confluent; they 

 remain as discrete bodies having definite lines of demarcation. 

 Since the action of this type of extract depends in the normal 



