OVARY AND THE ANTERIOR PITUITARY BODY 167 



discover whether other tissues and body fluids possessed the same 

 active principle. Zondek and Aschheim (658) found that the 

 implantation of o-i gm. placenta produced ovulation, while blood 

 serum and urine of pregnancy were active in amounts of 0-5 c.c. 

 and 1-2 c.c. respectively. The blood of a pregnant cow was 

 found to contain even larger amounts (659). Zondek and Asch- 

 heim thus suppose that elaboration of the hormone is more rapid 

 during pregnancy, and since it is absent in the urine of the 



End of 

 iincnstruation 



Monti) of preg-nancy 



Days 

 postpartum 



Anterior pituitary = Ovarian hormone 



hormone (oeatrin) 



Fig. 63. — Diagram of amount of CEstrin and anterior Pituitary 

 Substance in the Urine of Pregnancy. 



(From Aschheim and Zondek. 



non-pregnant female, its occurrence in the urine of early preg- 

 nancy is used as a test of this condition in the early stages (39). 

 By means of their technique (see p. 165) for separating and 

 testing the anterior pituitary hormone and oestrin in the urine, 

 they are able (40) to give the relative concentrations in the urine 

 during the course of pregnancy as shown in Table 11 and fig. 63. 

 Eels (204) also reports the hormone in the blood during 

 pregnancy. The significance of the occurrence of this large 

 amount of anterior pituitary substance in the urine of pregnancy 

 is not as yet understood. 



