1MB] VETERINARY MEDICITTB. 287 



The globoid bodies of poliomyelitis were found to grow readily in ancoagalated 

 human blood, while they failed to grow when Beeded Is ancoagalated rabbifa 

 blood. 



The hypothesis advanced to explain the facts observed Is that "when small 

 □umbers of bacteria are planted In fresh, ancoagalated blooC only those bacteria 



grow and multiply which are pathogenic for the s] les f. which the blood 



is drawn. Further, the number of given organisms destroyed bj blood from 

 different species is, to a certain extent, proportional to the natural immunity 

 of those species to the organism. This likewise appears to be true of the im- 

 munity Induced by inoculations." 



Researches on the abnormal figures for sodium chlorid in the serum of sick 

 horses, ArorsTix (Rev. Clen. Mr<l. I <7., j? (1918), No. SSI, pp. .',.'■' ;.;.;). — Ob- 

 servations are reported showing that the sodium chlorid in the serum of boi 

 is susceptible to wide variations in the course of Infections of the pasteurella 

 type, an ascending curve of temperature very often coexisting with a descend- 

 ing curve of sodium chlorid. In the course of protracted convalescence a nor- 

 mal temperature is accompanied by a high sodium chlorid figure. 



It is recommended that, in severe infections where injections of physiological 

 serum are employed, 5.5 or 6 gm. of sodium chlorid per 1,000 should replace 

 the concentration of 7 or 7.5 gm. per 1.000 usually employed, in order not to 

 change too abruptly the strength of the sodium chlorid in the blood. The author 

 also recommends the daily administration of about 200 gm. of sodium chlorid 

 .:s an essential adjuvant t<» the ordinary medication. 



The influence of arsphenamin and mercuric chlorid upon complement and 

 antibody production, I. Toyama and J. A. Kot.mer (■four. Immunol., 3 (1918), 

 No. -'/. pp. 301-316; ab8. in -four. Aincr Med. ASSOC, 11 (1918), No. .'.). pp. 2081, 

 1022). — A study is reported of the probable influence of arsphenamin and of 

 mercuric chlorid upon (1) the production of immune antisheep and antihuman 

 hemolysins and agglutinins for sheep and human erythrocytes in rabbits, 

 (2) the production of immune typhoid agglutinin in rabbits, (3) hemolytic 

 complement and normal antisheep hemolysin in rabbit serum, and (4) normal 

 typhoid agglutinin and hemolytic complement in human serum. 



The general result of the experiments indicates that while massive di 

 of arsphenamin and mercuric chlorid tend t<> suppress antibody production and 

 cause a decrease in hemolytic complement, smaller doses tend to Increase the 

 production of antibody agglutinins and augment the complement content after 

 a primary decrease. 



On the concentration of antitoxic sera, Axnii: Homes (Jour. Physiol., ■' .' 

 (1918), No. '/. pp. XXXI-XXXIII). — Additional suggestions to those previ- 

 ously noted (B. S. R., 39, p. 487) are given tor the concentration of antitoxic 

 -era. If cresylic acid is to be used (E. S. R., 38, p. 504), it is considered ad- 

 visable to determine experimentally for each consignment the minimum amount 

 necessary to produce clear end-points. Preliminary adjustment of the reaction 

 of the plasma to pH S.3 is thought, however, to give more reliable results than 

 those obtained by the use of either phenol or cresylic acid. 



If both the first and second fraction precipitates are to he extracted with 

 brine, the author recommends that, instead of altering the plasma after the 

 addition of 30 per cent ammonium sulphate, the ammonium sulphate content he 

 brought up to 46 or 50 per cent saturation and the liquid then tillered. The 

 precipitates, consisting of those of both the first and second fraction precipi- 

 tates, are macerated in a volume of brine about twice that of the original 

 plasma, salt is added, and after standing at room temperature for at least 

 three days the brine extracts are filtered. To the filtrate is added 0.3 per cent 



