578 EXPERIMENT STATION RECORD. [Vol.4.. 



" V. srjjtique Is essentially an organism whose activities are directed to an 

 attack on carbohydrates. It grows freely in so-called carbohydrate-free media, 

 producing considerable quantities of gas, but the addition of a carbohydrate 

 accelerates metabolism. The acid production is not at all s<> marked as with 

 Bacillus toelchii. As a gas former In carbohydrate-containing media, it comes 

 within the range thai w;is found with B. toelcMi, but the process takes much 

 longer to reach a maximum. 



"A certain amount <»f proteolysis takes place which Is of the same order as 

 that obtained with /?. welchU, but it is in DO way commensurate with the attack 

 which the V. Septique makes npon carbohydrates." 



The results obtained with tryptic broth to which fresh rabbit kidney had 



1 n added confirm the work of other authors that the addition of a small 



amount Of animal tissue i" a medium which by itself does not actively promote 



owtb undoubtedly has a decided effect In stimulating the growth of the 

 anlsm. 



Immunity and tissue transplantation. — IV, The influence of immune 

 serum upon the reactions about transplanted tissues, M. S PLKI8HEB {Jour. 

 Med. /.'< tearch, 89 [1918), No. I, pp. / H). in continuation of Investigations 

 previously noted (E. S ft., 39, p. 888), experiments arc reported In which the 



Influence of Immune serum upon regeneration and leu lytic and connective 



tissue reaction was studied 



Pieces ( .f guinea pig kidney were transplanted Into the subcutaneous tissue 

 of the abdomen of guinea pigs and rabbit- passively Immunised with serum 

 obtained from rabbits Immunized agau st guinea pig kidney. For purposes of 

 comparison similar pieci '• pii: tissue w,.r.' v,, nked In rabbit anti- 



Berum and oth.-rs in norma] serum and later transplanted Into guinea pigs 

 and rabbits, 



It was found that In passlvelj Immunized animals the Bame reactions occur 

 about homolotransplants as in normal animals. This is also true of betero- 

 trahsplants, with the posslb ption of a slower clearing of the leu< 



from the peripheral portion of thi I In the case of tissue soaked in 



immune serum before transplantation there is probably a slight and brier 

 slowing of connective tissue reaction and regeneration in homolotransplants. 

 In heterotransplants there la Interference will. ration and a Blower Inva 



Blon by the l( acocj te 



it i- pointed out that "the results of these experiments suggest that sub- 

 stances i'i the body Quids of Immunized animals have but little Influence on 

 the regeneration of transplanted tissue, and that the Blowing of leucocytlc 

 invasion is in large part due to tin action of the serum The results further 

 Buggesl that the more marked leucocytlc reaction seen about transplants in 

 either Immune heterologous animals or immune homologous animals is ;i direct 

 and Independent manifestation of the immunity to the tissue if these conclu- 

 sions be correct, it appears that, In immunity to tissue transplantation, tissue 

 reactions and especially the reactions of leucocytes play a more important part 

 than do the reactions called forth or produced by the bodj fluids.*' 



Heterolysins. A. SoBOELU and <;. FlSCHEB {Rev. In*t Bad [ Irgentina], I 

 (1918), N- •■'././. , fig, i: Is Soc.Quim i ■ Una, 8 (1911 pp. 



,•: Y1, pp. ',','. \50; 28, pp 145). By Injecting the kldnej of gull 



pigs ami dogs, heterolysins for sheep and goats were obtained In rabbits, n 

 and cows, but not in pigeons and dogs No difference was observed b 

 the Isolyslns of the sheep and goats and the heterolysins obtained bj the 

 Injections of the kldnej of the dog npon their fixation power in contact with 

 sh.. p and goat i oi pusclea or with the kidney of the dog or guinea pig. 



