766 EXPERIMENT STATION RECORD. [Vol. -JO 



The results obtained appear t<> demonstrate no definite connection between 

 changes in acid-base equilibrium and creatin excretion. The authors point 

 out that the rations used in the above experiments and those reported earlier 

 (E. S. R., 37, P- 469) contain a much larger amount of protein than the so-called 

 high protein diets employed by Rose, Dimmitt, and Bartlett (EL S. EL, 38, p. 

 571), with which creatin excretion was not obtained. 



Normal mechanism for the control of oxidation in the body. W. EL BUBGS 

 and A. J. Nkii.i. {Amer. -lour. PhyaioL, \6 [1918), So. 2, pp. 117-127, tins. $).— 

 Continuing previous work ■ K. S. U„ 4i>. p. 364 ), an Investigation was undertaken 

 with laboratory animals (dogs, cats, and rabbits), from which the author con- 

 cludes that " ingestion of the foodstuffs increases the catalase of the blood and 

 hence of the tissues parallel with the increase in heat production The increase 



in catalase is due mainly to the stimulating effect of the absorbed foodstuffs 

 on the liver. The Ingestion <>f protein, in keeping with its greater stimulating 

 effect on heat production, produces a greater increase in catalase than fat or 

 carbohydrate. After the removal of the liver from the body of an animal, the 

 liver ceils continue t<> liberate catalase for about two hours, due presumably to 

 the stimulating effect of the dextrose Conned from the glycogen." 



The effect of acetone and of 0-hydroxylbutyric and acetoacetic acids on 

 the blood catalase, W. EL Bubsi {Jour. Biol Cht in.. XI {1919), No, S, pp. 3^3- 

 ,?.}7, flgs. j). in continuation of the Investigations on catalase noted above, 

 the anther reports experiments indicating that the introduction into animals of 

 acetone and of ,- hydroxylbutyric and acetoacetic acids results In an increase in 

 the catalase in the blood, and that this Increase is due to a stimulation of the 

 liver by these substances. This is thought to offer an explanation of the In- 

 creased oxidal ion in diabetes 



Contributions to the physiology of the stomach. — XLVII. Gastric secretion 

 and urine ammonia. A. Q l\v i \nirr. Jour. PhutioL, }'>' {1918), v " /. /'/>• -■ 

 361, figs. 'it. — The author concludes that "gastric secretion and urine ammonia 

 are related in that the urine ammonia is increased by the absorption in the 

 Intestine of the acid product of gastric secretion, provided that this add secre- 

 tion is absorbed before neutralization occurs, i. fc, at a relatively fast rate." 

 For earlier work see a previous note i K. S. K.. 40, p. 270). 



Contributions to the physiology of the stomach. — XLVIII. Studies in water 

 drinking, A. ('. I\v ( \w> r. -lour. PhytioU, ','< {1918), \" /. /'/'• /-'" )>-■ 

 in. -From observations upon laboratory animals (dogs) and man the author 

 uraws the following conclusions: 



"The Ingestion of water with the meals (400 to SIHI CC) increases the amount 

 and the free and total acidity of the gastric juice. The Ingestion of water with 



the meals decreases the emptying time of the stomach, due to the dilution of 



the stomach contents. Food in the stomach retards the evacuation of water. 

 The emptying time of water from the normal human stomach varies, conserva- 

 tively, from 400 cc. to 100 cc. in 16 minutes. 



"The manner of the discharge of water from the dog's stomach is. according 

 to the observations upon 4 dogs, rhythmic and could very possibly correspond 

 to peristaltic waves. All stomachs do not respond to stimulation by water, there 

 beim: a marked variation in different Individuals Those stomachs that empty 

 water slowly (150 cc. or less in IB minutes when (00 CC. are drunk) respond 

 much more than those that empty water last. From the observations in this 

 study water can not be substituted for the Fwahl meal. 



"The latent period of the gastric glands of man when Stimulated by water 

 is from 5 to 7 minutes, it was impossible to demonstrate a fatigue of the gastric 

 glands when stimulated le> water or by gastrin for a period of 10 to 'JG hours." 



