VETERINARY MEDICINE. 677 



Studies on the biochemistry and chemotherapy of tuberculosis. — X, An 

 experimental study of the influence of iodin and iodids on the absorption of 

 granulation tissue and fat-free tubercle bacilli, E. F. Hiuscu {Jour. Infect. 

 Diseases, 15 {1014), No. S, pp. 487-500) .—" The use of iodin and iodids in 

 facilitating the absorption of necrotic material and organization of tuberculous 

 and other granulation tissues has no experimental proof. The daily administra- 

 tion of potassium iodid does not hasten the removal of foreign substances, like 

 tubercle bacilli, by stimulating the phagocytic properties of the endothelial cells. 

 The presence of free iodin in such areas may influence the process only by 

 favoring an inflammatory reaction, if the amount of iodin is sullicient, but has 

 no effect in promoting absorption. Iodized fat-free tubercle bacilli are absorbed 

 no faster than are the noniodized." 



Studies on the biochemistry and chemotherapy of tuberculosis. — XI, The 

 therapeutic value of copper and its distribution in the tuberculous organism, 

 H. J. CoKPEE {Jour. Infect. Diseases, 15 {1914), No. 3, pp. 518-540). — "Copper, 

 in simple salt form (sulphate, acetate, oleate, and copper amino-acid mixture 

 prepared from hydrolyzed egg albumin), injected intramuscularly into normal 

 and tuberculous guinea pigs, in total amounts from 0.75 mg. up to about 19 mg. 

 for about 2 to 100 days, enters the animal organism and is found mainly and 

 in largest amounts in the liver, in small amounts in the kidneys, in traces in 

 the spleen, lungs, and blood, and not at all in the tuberculous lymph glands and 

 pus. After cessation of injections the copper slowly but gradually decreases in 

 amount in the liver. 



" Copper, in simple salt form, injected intramuscularly in guinea pigs in 

 amounts varying from 2.7 to 22.1 mg. during a period of 13 to 34 days, previous 

 to (19 days), coincident with (2 days before), or after (11 days) infection 

 with tubercle bacilli, has no appreciable effect upon the progress of the tuber- 

 culosis, as indicated by the lesions present after death. 



" Copper, in simple salt form, fed to rabbits in amounts up to 1,880 mg. of 

 copper, during a period of 97 days, and injected (copper sulphate and copper 

 amino acids) intramuscularly into rabbits, in amounts up to 5.5.1 mg. of copper, 

 during periods to 90 days, enters the blood and is found mainly and in largest 

 amounts in the liver, in small amounts in the kidneys, in traces in the lungs 

 and blood, and not at all in either the tuberculous or normal eyes. Copper, in 

 the form of copper sulphate, fed to rabbits in amounts of 1 to 2 cc. of a 1 per 

 cent solution daily for up to 100 days, begun 5 days before infection, has no 

 appreciable effect upon the course of the tuberculosis of the eye, as indicated 

 by the progress of the disease and the final weight of the eye. 



" Copper, in simple salt form, injected intramuscularly into rabbits, in amounts 

 of 12 to 42.9 mg. copper, for 37 days, begun on the eleventh day after infection, 

 has no appreciable effect upon the course of the tuberculosis of the eye, as indi- 

 cated by the development of the disease in the eye. 



" Colloidal copper, prepared electrolytically by Bredig's method, injected in- 

 travenously into normal and tuberculous rabbits in amounts totaling 9.6 mg., 

 fi'om 4 to 12 days, is found mainly and in largest amounts in the liver, in 

 smaller amounts in the kidneys, in traces in the lungs, and not at all in the 

 normal or in the tuberculous eyes. This distribution of colloidal copper seems 

 to favor the conception that copper in simple crystalline form, fed or injected 

 intramuscularly into the animal organism, does not circulate in this simple 

 form, but rather immediately forms colloidal combinations. If such is the 

 case, this would readily explain its inability to enter tuberculous tissues, since 

 It was found by Wells and Hedenburg that colloids (egg albumin) are not 

 suited as entrants into the tubercle or other necrotic areas. 



