182 EXPERIMENT STATION RECORD. 



kiilose, 20 (1913), No. 1, pp. 11-21; ahs. in Centbl. Bald. [etc.'\, 1. Abl., Ref., 

 58 (1913), No. 7-8, p. 234). — ^Apparently no significance can be attached to the 

 complement fixation reaction as regards the early diagnosing of cases of 

 luberculosis. 



Diagnostic and curative methods in bovine tubercuiOsis, ^. Ondracek 

 (TierlirzU. Zcntbl., 36 (1913), No. 32, pp. Ji88-J,91 ; aU. in BcrUn. TierdrzU. 

 Wchnschr., 30 (191J,), No. If, pp. 123, i^^).— This details the work done in 

 regard to the eradication of bovine tuberculosis in Goding, Austria. 



Up to 1909 Bang's procedure was used with good success, but the tuberculin 

 testing which was done in conjunction with the method caused a diminution of 

 tlie milli yield. After 1909 Klimmer's phyniatin eye test was employed. The 

 tuberculin (phymatin) is instilled in the morning, and the first temperature 

 observation Is made after 6 to 12 hours. Cows not reacting within this time 

 should be given another test after 24 hours. The curative properties of anti- 

 phymatol were studied with 59 cows, and an injection was made every three 

 months for a period of one year. In one barn very good results were obtained, 

 and in the other the results were not so good but satisfactory. 



Tuberculin and tuberculosis immunity, Deycke and Much (MUnehen. Med. 

 Wchnschr., 60 (1913), Nos. 3, pp. 119-121; 4, pp. 190-193; abs. in Chem. Abs., 

 7 (1913), No. 8, p. 1378). — "The authors continued previous studies with the 

 products of the ' Milchsaure aufschliessung ' of tubercle bacilli and com- 

 pared them with tuberculin (old). The matei'ial giving the tuberculin reac- 

 tion (subcutaneous tests) in the water solution filtrate was precipitated by 

 alcohol and alcohol-ether ; this precipitate gave the reaction, but it was only 

 equivalent (quantitatively) to that remaining in the alcohol and alcohol-ether 

 filtrates. There is a marked difference in the activity of the different fractions 

 for the intracutaneous reaction ; the protein is 1,000 times as active as the fatty 

 acid lipoid mixture, which is 10 times as active as the neutral fat. 



" There is also a marked difference between the protein and fatty substances 

 with regard to the appearance of the intracutaneous reaction; while the pro- 

 tein reactions appear in a few hours and completely develop in 1 to 2 days, 

 the fatty substances require a much longer time to develop, and for comple- 

 tion 1 to 2 weeks are necessary (the neutral fats being slower in action, appear- 

 ing in 3 to 4 days, than the fatty acid lipoid mixtures, appearing in 24 hours). 



" The authors discuss tuberculosis immunity on the basis of their experi- 

 ments with regard to cellular and humoral immunity." 



Investigations as to the therapeutic action of tuberculin for tuberculosis 

 in guinea pigs and rabbits, H. Haxtpt (Beitr. Klinik Tuberkulose, 23 (1912), 

 No. Jf, pp. 471-524). — No curative action could be ascribed to tuberculin when 

 artificially infected guinea pigs and rabbits were treated with this substance. 



Tuberculin as a curative agent, and a contribution to tuberculosis im- 

 munity questions, H. Hx\.upt (Berlin. Tiercirztl. Wchnschr., 30 (1914), Nos. 2, 

 pp. 28-30; 3, pp. 41-43; 4j PP- 60, 61). — After reviewing the literature on the 

 use of tuberculin and similar substances for curing tuberculosis, experiments 

 made with animals hypersensitized toward tuberculin are briefly reported (see 

 abstract above). The animal organism, according to the author, can form 

 tuberculosis antibodies after intravenous or subcutaneous injections of stand- 

 ardized tubercle bacilli antigens. 



Healed tuberculous processes are recognized by marked encapsulation with 

 connective tissue. These new formations (encapsulations) occur as soon as the 

 tuberculous foci take the form of foreign bodies, and these result only when 

 through the agency of the antibodies the tuberculous process has become checked. 



