VETERINARY MEDICINE. 179 



Starvation proceeds and the fat depots have been utilized, the ferments make 

 their appearance and can be noted by the Abderhalden methods. 



Nucleoproteins as antigens, H. G. Wells {Ztschr. Immunitdtsf. u. Expt. 

 Ther., I, Orig., 19 {1913), No. 5, pp. 599-611).— The author believes that pure 

 nucleins are probably not antigens in the ordinary sense of the term because 

 their constituents (nucleic acid, and histones or protamins) are not antigens. 

 Much depends upon the method of preparing the nucleoproteins, and there 

 exists no ground for assuming that these protein nuclein complexes are in a 

 measure si^ecific or characteristic of the cells from which they are derived. 



A review of the literatui'e is given. 



On the anemia produced by the injection of the nemolysin obtained from 

 streptococci, and on the question of natural and acquired immunity to 

 streptolysin, J. W. M'Leod and J. W. M'Nee (Jour. Path, and Bad., 11 {1913), 

 Ko. Jf, pp. 524-537, pis. 2). — "Rabbits vary in their susceptibility to injections 

 of streptolysin, the variation being, in part at least, due to differences in the 

 amount of natural antibody to streptolysin present in their sera. The more 

 susceptible animals die after one or two injections, evidently from a toxic 

 effect of the filtrate. Hemoglobinemia and hemoglobinuria are marked in these 

 animals, and the toxic and hemolytic properties of the filtrate are closely re- 

 lated. It has not been possible to demonstrate toxic effects of the filtrate after 

 destruction of the hemolysin by incubation at 37° O. The less susceptible ani- 

 mals survive repeated injections. No toxic symptoms occur, and a definite 

 anemia results. Slight hemoglobinuria follows as a rule when the filtrate in- 

 jected is a powerful one. 



" The changes in the blood are similar to those which have been produced 

 experimentally by other hemolytic agents. The bone marrow in the longer ex- 

 periments becomes markedly hyperplastic. The leucoblastic and erythroblastic 

 portions of the marrow as a rule react equally. The liver shows as marked a 

 hemosiderin reaction, post-mortem, as the kidneys and spleen. This contrasts 

 with experimental anemia in rabbits produced by injection of a hemolytic im- 

 nmne serum. In the greatly enlarged spleen of one animal a very marked 

 myeloid transformation was found. Large collections of myelocytes, many in 

 active mitosis, surrounded closely each Malpighian body. No immunity to the 

 streptolysin is produced even after repeated injections. On the contrary, a 

 slightly increased susceptibility may result. The amount of hemolysis produced 

 in vivo is much less than that which is produced in vitro. In the animal body, 

 as in the test tube, hemolysis does not continue for more than about two hours. 

 Hemoglobinemia is most marked after this interval, then gradually disappears." 



See also a previous note (E. S. R.. 28, p. 179). 



The method whereby streptococcic serum acts, E. Weil {Ztschr. Eyg. u. 

 Infektion^krank., 75 {1913), No. 2, pp. 245-310). — Streptococci do not intoxicate 

 by virtue of a true toxin or endotoxin and the nature of the poison is still un- 

 known. Polyvalent serum (Aronson) can be rendered inactive to the original 

 streptococcus by saturation with killed cultures. In order for the serum to act 

 the presence of living leucocytes is necessary. No antiaggressins are con- 

 tained in the serum and it is inactive toward most streptococcic strains ob- 

 tainable from man. Despite the polyvalent origin of the serum it contains only 

 one immune bo<ly, by means of which it acts upon strains toward which it has 

 an affinity, and only a few of the strains are capable of reacting in the horse. 



Abderhalden serodiagnosis of cancer, C. F. Ball {Jour. Amer. Med. Assoc, 

 62 {1914), No. S, pp. 599-602, fig. i).— This gives the results of tests and a 

 description of a new form of apparatus for making the test. 



The use of Abderhalden's reaction in carcinoma and tuberculosis, E. 

 Feankel {Berlin. Klin. Wchnschr., 51 {1914), No. 8, pp. 356-358) .—This is a 



