274 EXPERIMENT STATION KECOBD. 



Serum therapy in tetanus, G. Theisz (Allatorvosi Lapolc, 36 (1913), No. 34, 

 pp. 403-/,05; abs. in Berlin. Tierdrztl. Wchnschr., 30 (1914), No. 12, p. 204).— 

 Tetanus antitoxin is usually recommended only as a preventive, but the author 

 used it as a curative with good results. Large doses are necessary, however. 



''Tick paralysis" in man and animals, G. H. F. Nuttall ( Paraaitology, 

 7 {1914), No. 1, pp. 9.5-iO-i).— The author reviews and comments upon pub- 

 lished records of tick paralysis which have come to his attention since the 

 publication of the ])revious paper (E. S. R., 30, p. 182). 



The arsenical dip and its value in combating ticks and tick-transmitted 

 diseases, A. Theiler (Ztschr. Infektionskrank. u. Ilyg. Uaustiere, 16 {1914), 

 No. 1-2, pp. 1-26, figs. 3). — This article is based upon investigations and 

 observations of the author in South Africa. 



Perment-inhibiting' substances in tubercle bacilli. — Studies on ferment 

 action, XI, J. W. Jobling and W. Petersen (Jour. Expt. Med., 19 {1914), 

 No. 3, pp. 251-258, figs. 4)- — Much work has been done in an attempt to explain 

 the processes that lead to the production of caseation in tuberculosis. Some 

 have abscribed it to anemia, the tubercle being avascular, and others to the 

 action of toxins derived from the tubercle bacilli. 



This work shows that tubercle bacilli contain ferment-inhibiting substances, 

 which " brings us one step nearer a rational explanation of caseation in tuber- 

 culosis. Tubercle bacilli contain unsaturated fatty acids which, when saponi- 

 fied, have the property of inhibiting the action of ti*ypsin and leucoprotease. 

 In proportion to their iodin value these soaps are more active as inhibiting 

 agents than the soaps prepared from linseed, olive, and cod liver oils. The 

 activity of the soaps Is dependent on the presence of unsaturated carbon 

 bonds. Saturation of the soaps with iodin destroys their inhibiting action. 

 Soaps probably play an important part in the production of the condition known 

 as caseation in tuberculosis." 



A study of the ferments and ferment-inhibiting substances in tuber- 

 culous caseous material. — Studies on ferment action, XII, J. W. Jobling and 

 W. Petersen {Jour. Expt. Med., 19 {1914), No. 4, pp. 383-397, figs. 6).— Con- 

 tinuing work noted above it is now shown that " caseous matter obtained from 

 lymph glands which have not become secondarily infected contains substances 

 which inhibit enzym activity. These substances consist chiefly of soaps of the 

 unsaturated fatty acids. The inhibiting substances are present in relatively 

 smaller amounts when the caseous matter has become secondarily infected. This 

 is probably due to the dilution and washing out of the soaps. Ferments are either 

 entirely absent or present in very small amounts, unless the caseous matter 

 has become secondarily infected. 



" Caseous material from the lungs contains smaller amounts of the inhibiting 

 substances. This may be due to the acuteness of the process, which does not 

 permit an accumulation of the soaps, or to the binding of the soaps with the 

 ferments. Ferments are present in caseous pneumonia. In the whole emul- 

 sion the fei'ments are less active in an alkaline than in an acid reaction; but 

 removal of the soaps shows that those active in an alkaline reaction are also 

 present in considerable amounts. The previous treatment with iodin of case- 

 ous matter from both lymph glands and lungs increases the action of the 

 trypsin." 



The methods employed for experimental tuberculosis by inhalation, P. 

 CHAUssli {Rec. Med, Yet., 90 {1913), No. 14, pp. 267-274, fig- i).— A discussion 

 of methods, but more especially the one utilized by the author, with a descrip- 

 tion of the apparatus employed. The advantages of using good technique for 

 realizing a tuberculosis by inhalation are emphasized. 



