876 EXPERIMENT STATION RECORD. 



ferments could no longer attack it and break it down. Tiiat may be true, and 

 yet other proteins capable of sensitizing and producing anaphylactic shock can 

 be handled in a similar manner and retain their specificity, as shown by 

 Vaughn, Wells, and others." 



On the protective value of aqueous extract (Hiss) of leucocytes in acute 

 infections in animals, W. E. Youland, Jr. (Jour. Med. Research, 31 {1915), 

 No. 3, pp. 367-390). — Leucocytes probably do not contain neutralizing substances 

 within the meaning of immunity. Leucocyte extracts apparently exert their 

 actions upon animal infections only in the border line type of infections and are 

 without curative value in more constant conditions. See also a note by Archi- 

 bald (E. S. R., 31, p. 377). 



The effect of intraspinal injections of serums witli and without preserva- 

 tives, J. AuEB (Jour. Amer. Med. Assoc., 62 (1914), No. 23, pp. 1799, 1800). — 

 Experiments were carried out on dogs and monkeys to determine what effects 

 are produced when an antimeningococcic serum containing 0.3 per cent of either 

 tricresol or chloroform is injected subdurally. As control injections, horse 

 serum, without any presen-ative, and Ringer solutions were employed. 



It was found that dogs would tolerate up to 6 cc. and more per kilogram of 

 body weight of 0.3 per cent tricresol without danger, as a rule, provided that 

 an efficient artificial respiration is maintained. Monkeys would tolerate injec- 

 tions of more than 6 cc. per kilogram of body weight without any dangerous 

 effect on spontaneous respiration. 



" Tests with serums containing 0.3 per cent chloroform, 0.3 per cent ether, or 

 no preservative at all, showed that they exerted qualitatively the same efl:ects 

 when injected intraspiually as tricresol serum, but quantitatively the dis- 

 turbances of respiration and blood pressure were definitely less. Chloroform 

 serum caused in general a smaller effect on the respiration and blood pressure 

 than tricresol serum, but the best results were obtained with 0.3 per cent ether 

 serum and with serum without any preservative, although both still occasion- 

 ally produced in the dog stoppages of the respiration lasting a minute or two 

 and a considerable lowering of the blood pressure. In the monkey, however, 

 normal serum or ether and chloroform serum produced practically only neg- 

 ligible effects on the respiration and blood pressure. . . . 



" It should be emphasized that respiratory failure is the great danger after 

 tricresol injection in the dog, and that it occurs only rarely in the monkey." 



Preliminary note on the presence of agglutinins for the Micrococcus 

 inelitensis in the milk and blood serum of cows in London, J. C. Kennedy 

 (Jour. Roy. Army Med. Corps, 22 (191^), No. I, pp. 9-14, flff- 1; a&s. in Jour. 

 Compar. Path, and Ther., 27 (1914), No. 2, pp. 185, i86).— Although agglutina- 

 tion was noted in some samples in dilutions of 1 : 20, there were a few reactions 

 in dilutions of 1 : 300. M. meUtensis could not be isolated from either market 

 milk or milk obtained directly from individual cows. When diluted milk was 

 passed through porcelain filters the property of agglutination was reduced 

 considerably. 



Revised rules and regulations for the suppression and eradication of in- 

 fectious and contagious diseases affecting live stock in the State of Georgia, 

 effective on and after December 1, 1912, P. F. Bahnsen ( [Off. State Vet. Go.], 

 Bui. 7, Ser. A (1912), pp. 29). — This is a compilation of the rules and regula- 

 tions promulgated which became effective December 1, 1912. 



Foot-and-mouth disease, F. Proescheb (N. Y. Med. Jour., 101 (1915), No. 8, 

 pp. 351, 352, figs. 5). — The success obtained with methylenazur with certain 

 filterable viruses suggested the application of the method to other unknowm fil- 

 terable viruses. Material obtained from the pustules of two typical cases of 

 foot-and-mouth disease (in Europe) in cattle showed that with the " usual bac- 



