VETERINARY MEDICINE. 879 



pp. 105-166: ahs. in Jour. Compar. Path, and Ther., 27 (191^), No. 1, pp. 83-85).— 

 This work, the second series of investigations, was carried out with a view to 

 ascertaining (1) the frequency of tuberculous infection, latent or manifest, ia 

 childhood; (2) the distribution of the disease within the body; and (3) the 

 relative Incidence of the bovine and the human types of the tubercle bacillus. 

 The tests employed to distinguish between the human and bovine types of 

 bacilli were the cultural characters .shown by growths upon glycerinized media 

 and the virulence for certain species of animals. Attention is drawn to certain 

 important factors in carrying out the virulence tests. 



" In all, 91 strains from various sites in the bodies of 35 children were tested; 

 of these strains 21 were obtained direct and 70 through the guinea pig. Seventy- 

 two strains from 28 cases exhibited the cultural characters of the human 

 tubercle bacillus, and 16 strains from 6 cases grew like bovine tubercle bacilli. 

 In every case from which two or more strains were isolated the cultural char- 

 acters of the strains were identical. In one case, a child aged five years who 

 died from meningitis, both human and bovine bacilli were proved to have been 

 present in the bronchial glands. The cultures in this case were obtained through 

 guinea pigs. . . . None of the bovine strains was isolated from children over 

 four years of age. . . . 



" Bacilli of the human type were isolated from 26 diseased children and from 

 two that were apparently healthy. In 16 of the 26 the bronchial glands were 

 most severely affected." 



Guinea i)igs were inoculated with material from apparently healthy bronchial 

 and mesenteric glands obtained from children showing no macro-scopic evidence 

 of tuberculosis and in only two cases were tubercle bacilli found. These were 

 of the human type. 



" With regard to the portal of entry the following points may be noted : Of 

 eight cases in which the intestines or mesenteric glands were the seats of the 

 primary lesions, six were caused by bovine bacilli and two by the human type. 

 Of 22 cases in which the primary lesions were intrathoracic the whole were due 

 to human tubercle bacilli. Since there is no recorded instance of a child suffer- 

 ing from primary thoracic tuberculosis caused by the bovine bacillus, and since 

 there are no grounds for assuming that the two types behave differently, it 

 must be held that the evidence tends to prove that in those cases in which 

 primary thoracic tuberculosis caused by the human bacillus exists the path of 

 infection has been the respiratory tract." 



Analysis of the reaction to tuberculin, F. Klemperee (Beitr. Klinilc Tuber- 

 kulose, 30 (IDUf), No. 3, pp. Jf,ll-4'f5, fit/s. 2^; ahs. in Jour. Amer. Med. Assoc, 

 62 (1914), ^0. 24. p. 1932). — It was found impossible to render nontuberculous 

 animals susceptible to tuberculin by the preliminax'y injection of tuberculin. 

 Consequently the tuberculin reaction can not be considered a phenomenon of 

 anaphylaxis. Animals with a local tuberculous process lose their susceptibility 

 to tuberculin for a time after the local process is excised. This apparently 

 shows that the tuberculin reaction is not due to antibodies circulating in the 

 blood. 



Tracings and tabulated details of the experiments on rabbits and guinea pigs 

 and .some clinical data are given. 



An aid to prognosis in pulmonary tuberculosis. A simple urinary test: 

 The urochromogen reaction of Weisz, J. Metzgeb and S. II. Watson {Jour. 

 Amer. Med. Assoc, 62 (191^), No. 2Ji, pp. 1886-1888).— The Weisz urochromogen 

 test was tried on 113 patients. The conclusions drawn are as follows: 



" The presence of a urochromogen reaction in the urine of a patient sick 

 with pulmonary tuberculosis is for the time being of unfavorable prognostic 

 import. The persistent presence of a urochromogen reaction in the urine, in 



