880 EXPERIMENT STATION RECORD. fVol. 37 



tuberculosis, could be demonstrated ; and cases in which the sputum alone was 

 examined. 



The cases coming under the third group have been previously repurtetl.' as 

 well as those under the fourth group (E. S. R., 37, p. 180). 



The 123 strains of tuberculosis bacilli obtained from 88 cases under groups 1 

 and 2 were investigated bacteriologically and found to conform to either human 

 or bovine types of the bacillus. No atypical strain was demonstrated. When 

 two or more strains were isolated from a single case their cultural charac- 

 teristics were identified. Out of 68 cases of adults, bovine tubercle bacilli 

 were separated in 7 instances, 1 from 29 sputum cases, 2 from 4 cases of 

 abdominal tuberculosis, 2 from 7 cases of generalized tuberculosis, and 2 from 

 28 cases in which the only signs of the disease were the calcareous or caseous 

 lesions. Three of the bovine cases gave indication on post-mortem examination 

 that the path of infection was by way of the intestine. In three others the 

 evidence of primary infection was inconclusive, while in the remaining case 

 (sputum case) no post-mortem was performed. 



The bacteriological examination of 20 cases in children resulted in the isola- 

 tion of the bovine type in 11 instances. In 9 of these cases the primary site 

 of infection was found to be in the intestine. In the remaining 2 instances the 

 evidence was inconclusive. 



The protocols of the cases of groups 1 and 2 are submitted, together with 

 the bacteriological data. In detailed tabular form. 



A bibliography of 26 references to the literature is appended. 



Tuberculosis in carnivorous animals, W. R. Blair (Jour. Amer. Vet. Med. 

 Assoc, 51 (19 J7), No. 6, pp. 750-767). — This is a general di-scussion of the preva- 

 lence, symptoms, and lesions of the disease, together with a number of case 

 reports of dogs, cats, and other carnivorous animals in captivity. 



The author's experience in the use of tuberculin as a diagnostic agent in 

 dogs has been unsatisfactory. Its use on cats is indicated as being uncertain, 

 and dangerous for animals free from the disease. 



Tuberculosis in the horse, F. Chambeks (Vet. Jour., 75 (1917), No. 505, pp. 

 2If2, 2^3). — The author reports four cases of tuberculosis in the horse, the 

 diagnosis of which was made on post-mortem examination. Autopsical data 

 are included. 



During the life of the animals tuberculosis was not suspected in any of 

 these cases. It is thus indicated that all cases of general debility which show 

 no improvement in a few weeks should be tested for tuberculosis. 



Antituberculosis vaccination, Rappin (Compt. Rend. Acad. Set. [Paris], 16.^ 

 (1917), No. 10, pp. Jf21, 422). — The preparation of a vaccine which yielded gootl 

 results is described as follows : 



Tubercle bacilli obtained from bouillon cultures of different ages and desic- 

 cated for 24 hours are treated with a 2 or 3 per cent solution of sodium fluorid 

 for several days. By this treatment the organisms lose their infective powers 

 but retain their toxic properties. The bacilli are washed with physiological 

 salt solution and then submitted for a longer or shorter period to the action 

 of an antituberculosis serum. This emulsion of the bacilli in the serum con- 

 stitutes the vaccine. 



Effect of tethelin on experimental tuberculosis, H. J. Corpeb (Jour. Infect. 

 Di^eascK, 21 (1917). Xo. S, pp. 269-278). — The subcutaneous injection of 25-mg. 

 doses of tethelin, isolated by Robertson (K. S. R., 3.5. p. 8), on alternate days 

 for 18 days into guinea pigs infected with virulent human tubercle bacilli had 

 no appreciable effect on the progress of the disease or the duration of life of 



1 Lancet [London], 1916, II, No. 10. pp. 417-419. 



