1917] VETEBINARY MEDICINE. 689 



tt is effective, for it then attaclcs the poisonous substance as it passes through 

 the abomasum. 



Studies In forage poisoning', IV, R. Gbaham and L. R. Himmelberger (Jour. 

 Amer. Vet. Med. Assoc, 51 (1917), No. 2, pp. 164-187, figs. 6).— This report is 

 based upon Investigations conducted at the Kentucky Experiment Station and 

 previously noted (E. S. R., 36, p. 581). 



During the course of investigations in connection with a definite outbreak of 

 forage poisoning various types of microorganisms that proved to be quite uni- 

 formly poisonous to horses and mules were isolated from oat hay. Among 

 these was a spore-forming, Gram negative, aerobic bacillus which was patho- 

 genic for horses and mules and less so for cattle, sheep, and goats, but to which 

 guinea pigs, rabbits, and white mice were apparently imnmne. Sterile fil- 

 trates of this bacillus subsequent to dally intravenous injections in some ex- 

 perimental horses proved pathogenic and capable of exciting clinical mani- 

 festations somewhat analogous to affected animals in the original outbreak as 

 the result of feeding on oat hay. 



The bacillus previously noted (E. S. R., 36, p. 581) was isolated from silage 

 in a remote outbreak of forage poisoning among cattle. 



Cottonseed meal work, W. A. Withers (North Carolina Sta. Rpt. 1916, pp. 

 19, 20). — This is a brief review of investigations during the year of the toxicaty 

 of cottonseed meal which have confirmed the views previously presented 

 (E. S. R., 34, p. 381) that gossypol is the toxic substance of cottonseed. 



Blackleg filtrate, A. Eichhorn (Jour. Amer. Vet. Med. Assoc., 51 (1917), 

 No. S, pp. 4O6-4IS; Ariier. Jour. Vet. Med., 12 (1917), No. 6, pp. 575-57S).— The 

 biological products proposed and u'^ed in blackleg are briefly reviewed. Prepa- 

 ration of a filtrate from media containing meat upon which the organism was 

 grown until no more gas was produced, together with a procedure for its 

 standardization, is noted. 



The filtrate is considered to be an effective immunizing agent, conferring an 

 active immunity which protects cattle against blackleg for as long a time as 

 the germ-free extracts prepared from the juices of the tissues of affected 

 animals. The losses incidental to vaccination with the powder or pellets are 

 entirely avoided, since the preparation does not contain the blackleg germ. 



The material in a concentrated form was found to retain its potency for 

 almost an indefinite time. The necessity of the usual sterility tests of the 

 filtrate, in order to guard against possible contamination, is indicated. 



The virulence of the blood of animals affected with foot-and-mouth dis- 

 ease and immunity tests, G. Cosco and A. Agxjzzi (Oior. Med. Vet., 66 (1917), 

 No. 14, pp. 31S-320). — This is a brief report of the investigation ordered by the 

 Italian minister of the interior in 1910. The topics treated are incubation, 

 fever, time of maximum virulence of blood, virulence of red blood corpuscles, 

 minimum dose of blood, increase of virulence of red blood corpuscles, tempo- 

 rary infection through the mouth, intravenous injection, and immunity tests. 



Allergic reaction of mallein for the diagnosis of glanders, E. Fava (Arch. 

 Set. Med. Vet. [Turm], 14 (1916), No. 1-12, pp. 1-lSl, figs. 27).— The author 

 describes and submits experimental data obtained through the application of 

 the subcutaneous, ophthalmic, and intrapalpebral mallein tests, and discusses 

 the specificity of the intrapalpebral reaction and its advantages over the other 

 methods of malleiuization, the intrapalpebral test for the prophylaxis of 

 glanders, and its application. 



It is concluded in general that the Intrapalpebral test posseses advantages 

 over the other procedures for the diagnosis of glanders, the advantages being 

 those essentially noted by other investigators. 



