IQQ EXPEEIMENT STATION KECORD. [Vol.35 



hemolytic serum and that which is more than 24 hours old should not be used 

 in the dialysis procedure. From the experimental results, it is concluded that 

 on account of the presence of the digestive ferments in the serum of the horse 

 the dialysis procedure for the detection of pregnancy is only of value when 

 it can be definitely established that the serum is nearly free from these fer- 

 ments. 



Investigations on the control of foot-and-mouth disease with " rindol," 

 Matthiesen and GiAssee (Berlin. Tieriirztl. Wchnschr., 32 {1916), No. 10, pp. 

 109-114) .—The authors have demonstrated that the preparation " rindol," 

 administered as directed by the producer, has no curative effect on diseased 

 animals, nor does it confer any immunity on healthy animals which may sub- 

 sequently be exposed to infection. The experimental data, together with the 

 clinical findings, are reported in detail. 



Contributions to the serodiagnosis of glanders; the use of polyvalent ex- 

 tracts in the examination of the serum for complement deviation, W. 

 Pfeileb {Berlin. Tierdrztl. Wchnschr., SI {1915), Nos. SJ,, pp. 397-403; 85, 

 pp. Jfll-fjlS). — Experimental data obtained in the course of an investigation on 

 the improvement of the serodiagnostic methods for the detection of glanders 

 are submitted. It was found that the use of polyvalent extracts in the com- 

 plement-deviation procedure increased the sensitiveness of the reaction consid- 

 erably. The experimental results are discussed in detail. 



The agglutinin, precipitin, and complement-deviating substance content 

 of the aqueous and vitreous humor and other body fluids of glanderous 

 horses, Borchardt {Arch. Wiss. u. Pralct. Tierheilk., 41 {1915), No. 6, pp. 573- 

 425). — It has been observed that the synovial fluid and the serous fluids of the 

 pericardial, peritoneal, and pleural cavities contain appreciable amounts of 

 agglutinin, precipitin, and complement-deviating substances. The aqueous and 

 vitreous humor, however, contains none, or only extremely small amounts, of 

 these antibodies. 



A bibliography of 63 references cited is appended. 



The toxicity of the blood serum of luetics for anaphylactic (sensitized) 

 guinea pigs, AV. Misch {Ztschr. Imrnunitdtsf. u. Expt. Ther., I, Orig., 24 {1916), 

 No. 4, pp. 3S0-386). — Human syphilitic serum is found to be more toxic for sen- 

 sitized guinea pigs than the serum of nonsyphilitics. This phenomenon is not 

 manifested when normal untreated guinea pigs are injected with the respective 

 sera. It is indicated that this increased toxicity of luetic serum is caused by 

 an increase of proteins in the serum, especially globulins. 



Observations upon complement fixation in the diagnosis of pulmonary 

 tuberculosis, C. F. Craig {Amer. Jour. Med. Sci., 150 {1915), No. 6, pp. 781-791; 

 ahs. in Internal. Centbl. Gesam. Tuherkulose Forsch., 10 {1916), No. 2, p. ^6). — 

 Experimental data presented demonstrate that " complement-binding antibodies 

 are present in the blood serum of both active and clinically inactive tuberculous 

 Infections. A polyvalent antigen prepared from several strains of the human 

 tubercle bacillus has been found to give excellent results in complement fixation 

 for tuberculosis. With the test described complement fixation gave a posi- 

 tive reaction in 9G.2 per cent of cases of active tuberculosis and in 6G.1 per 

 cent of the cases of clinically inactive tulierculosis. The test was negative in 

 normal Individuals and in patients suffering from other diseases with the ex- 

 ception of two patients inf{>cted with syphilis in whom symptoms of a coin- 

 cident tuberculous infection was also present. The test does not give positive 

 results with the blood serum of syphilitics in whom there is no coincident 

 tulierculous infection. The reaction, when positive, is specific and apparently 

 indicates the presence of an active tuberculous focus, although there may be 

 no symptoms of the disease present. Positive results are obtained in a large 



