280 EXPEEIMEKT STATION KECOED. [Vol.35 



from that fluid. There is no evidence that antibodies originate from the tissues 

 and are emptied into the lymph stream at the seat of formation." 



Researches on anaphylaxis produced by diglycylg'lycin, E. Zuntz and 

 Mlle. Diakonoff (Biochem. Jour., 10 (1916), No. 1, pp. 160-168). — Anaphylaxis 

 was produced by the injection of diglycylglycin into rabbits repeated at intervals 

 of seven days. Three injections w^ere occasionally sufficient to produce this 

 effect, but a greater number were preferable for producing clear and definite 

 results. The typical symptons of anaphylactic shock, viz, fall of arterial pres- 

 sure, increased respiration, and increased peristaltic action, were produced by 

 these injections. A fall in the arterial pressure of more than 2 cm. of mercury 

 was considered as an indication of anaphylactic shock. The intravenous injec- 

 tion of the peptid into a normal animal led to no effect on the normal respiratory 

 rhythm. ■ 



The diglycylglycin also displayed some action on the coagulation of the blood. 

 A study of the coagulability of the blood, however, did not serve as a criterion 

 for determining anaphylactic shock in animals previously prepared by the sub- 

 cutaneous injections of the peptid. 



Remarks on the nature and significance of the so-called " infective gran- 

 ules " of protozoa, E. A. Minchin (Ann. Inst. Pasteur, 29 (1915), No. 11, pp. 

 537-544, figs. 2). — "This brief note does not bring forward any facts hitherto 

 unknown, but attempts to compare and coordinate certain known facts with a 

 view to demonstrate their essential similarity and howiology. The conclusion 

 reached is that the phrase ' infective granule ' is misleading and erroneous, since 

 the bodies so termed are true endogenous chromidial buds. Consequently the 

 term ' granule-formation ' should be replaced by ' endogenous bud formation ' 

 and the term ' granule shedding ' by extrusion of buds or some similar phrase." 



On the action of cholera virus in the immune animal organism, O. Bail 

 (Ztschr. Immunitdtsf. u. Expt. Ther., I, Orlg., 24 (1916), No. 4, pp. 396-410).— 

 It has been shown that the union of cholera immune serum with the virus of the 

 cholera vibrio in its various forms is not a permanent one, but that a cleavage 

 takes place by which, on the one hand, serum-immune bodies are formed, as 

 indicated by the earlier investigations of PfeifCer, Friedberger, and Bail, and 

 at the same time cholera virus is liberated which can be demonstrated either by 

 complement fixation or animal inoculation. To this liberation of cholera virus 

 is attributed the weak antitoxic action of anticholera sera. The necessity of 

 the preparation of a serum which will permanently bind the cholera virus (endo- 

 toxin) is indicated. 



[Foot-and-mouth disease], L. Hoffmann (Bekdmpfung der Maul- und 

 Klavenseuche durch Heilung der kranken Tiere, I and II ; Sichere und rasche 

 Bekdmpfung und Vertilgung der an sich harmlosen Maul- und Klavenseuche, 

 III; Heilung der Kranken und Vertilgung der Maul- und Klauenseuche nach 

 meinem System, IV. Stuttgart: Stdhle d Friedel, 1912, Nos. 1, pp. VIII-\-100, 

 pi. 1, figs. 2; 2, pp. XVI+101-292, figs. 49; 1914, Nos. 3, pp. 293-408, pi. 1, figs. 

 4j 4. PP- 409-502). — The first two parts of this work deal with the combat of 

 foot-and-mouth disease through the curing of affected animals ; part 3 with the 

 control of the disease ; and part 4 with the cure and eradication of the disease 

 by the author's method. 



[Poliomyelitis: Its possible occurrence in the lower animals and the rela- 

 tion of insects to its transmission] (Ann. Rpt. Bd. Health Mass., 45 (1914), 

 pp. 535-601. pi. 1). — Several papers here presented include the following: Fur- 

 ther Experiments in Poliomyelitis, by M. J. Rosenau (pp. 535-557), in continua- 

 tion of those previously noted (E. S. R., 28, p. 160), which reports transmission 

 experiments with the stable fly (Stomoxys calcitrans), largely in tabular form; 

 Experiments to Determine If Paralyzed Domestic Animals and Those Associated 



