484 EXPERIMENT STATION RECORD. [Vol.35 



ing sucrose. The invertin can be demonstrated in the blood after injection of 

 such an enzym extract. It soon disappears from the circulation, and can no 

 longer be detected in the serum at the end of from 20 to 24 hoiirs. The better 

 utilization of sucrose thereupon does not continue to be manifested. Invertin 

 was not excreted into the urine. , . . 



" Examination of the serum of dogs and rabbits after repeated parenteral 

 injections of sucrose in both small and large doses has uniformly failed . . . 

 to demonstrate the presence of invertin in amounts detectable by the methods 

 employed. Glucose was likewise unaltered by the sera of the animals exam- 

 ined." 



See also a previous note by Rohmann (E. S. R., 34, p. 675.) 



The intravenous iBJection of magnesium sulphate for anesthesia in ani- 

 mals, J. AuEB and S. J. Meltzeb {Jmir. Expt. Med., 23 (1916), No. 5, pp. 6^1- 

 653). — Experimental data submitted show that "by the intravenous injection 

 of fourth-molar magnesium sulphate into dogs at a certain rate, a stage can 

 be reached where the abdominal walls are completely relaxed and when section 

 of the abdomen and stimulation of sensitive parts of the parietal peritoneum 

 do not produce pain or elicit any reaction of the animal. At the same time 

 spontaneous respiration may still be maintained within normal limits and the 

 lid reflex be fair or even normal. In this stage intratracheal intubation for 

 artificial respiration can be easily accomplished. This stage may be attained 

 in 12 to 14 minutes when the rate of injection is about 3 cc. per minute. 



"When this stage is once attained the rate of injection should gradually be 

 reduced, otherwise, sooner or later, spontaneous respiration will be abolished, 

 and by a further maintenance of the rate of injection all the skeletal muscles 

 may become paralyzed. When the injection of magnesium is continued for a 

 longer period the paralytic effects of the magnesium injection will set in, even 

 when administered at a slow rate. 



"The paralysis of the respiratory function is readily met by intrapharyngeal 

 insufflation, which is easily executed even without training in this procedure, 

 or by the method of intratracheal insufflation, if executed by one trained in its 

 management. When the respiration of the animal is accomplished by insuffla- 

 tion, the paralytic effect of the magnesium may be abolished fairly rapidly by 

 an intravenous injection of about 10 cc. of an eight-molar calcium chlorid solu- 

 tion ; or it may disappear slowly, after the infusion of the magnesium solution 

 is discontinued for some time. The latter mode of disappearance may be favor- 

 ably accelerated by an intravenous infusion of 60 to 100 cc. of a fourth- 

 molar solution of sodium sulphate." 



It is indicated that the production of anesthesia by the intravenous injection 

 of magnesium should not be undertaken unless an apparatus for intra- 

 pharyngeal insufflation is at hand. Calcium chlorid should not be employed 

 in cases in which the subject shows cardiac insufficiency, nor should the method 

 of producing the anesthesia be used in such instances. 



Some fallacies regarding phenol, M. I. Wilbebt {Pub. Health Rpts. [U. S.], 

 31 {1916), No. 17, pp. 1046-1051). — Experiments in which the germicidal value 

 of mixtures of phenol and ethyl alcohol and of phenol and glycerin was de- 

 termined are reported, together with experiments on the effect of ethyl alcohol 

 or glycerin on the toxicity of phenol, as shown by inoculations into white mice. 



From the experimental work it is concluded that "the addition of ethyl 

 alcohol to phenol not only increases the solubility of phenol in water, but also 

 increases rather than diminishes the antiseptic value of the resulting solution. 

 Ethyl alcohol can be used to advantage as a substitute for glycerin in making 

 antiseptic solutions of phenol. . . . The addition of ethyl alcohol to solu- 



