782 EXPERIMENT STATION RECORD. f Vol. 35 



tion of a foreign serum into a guinea pig. After about 17 days the antigen 

 apparently disappears from the cells and blood. Antibody is demonstrable in 

 the cells from the ninth day onward, and in the blood after the fourteenth day. 



"The interrelations of these four factors are probably very complicated. For 

 a period of several days all may coexist in the body." The earlier observation 

 that after partial desensitization both antigen and antibody may be demon- 

 strated in the cells has been confirmed. 



See also a previous note by Weil (E. S. R., 34, p. 778). 



The effects of vaccine sensitized with hom.ologous immune serum, as 

 compared with those of a nonsensitized vaccine: An experimental study, 

 S. Kakehi (Jour. Path, and BacL, 20 (1916), No. If, pp. 410-U3, figs. 5).— From 

 the investigation reported, using the Bacillus pseudotuberculosis rodentium, it 

 was found that " the sensitized vaccine has one slight advantage in that the in- 

 crease of temperature in injected animals is a little lower on the average than 

 that produced by the nonsensitized, not only after the first injection, but also 

 after succeeding injections." 



In the use of the sensitized vaccine a much smaller loss of weight was ob- 

 served than when the nonsensitized vaccine was used. No appreciable difference 

 in the degree of immunity conferred by each kind of vaccine was noted, as about 

 the same degree of resistance against various lethal doses was manifested by 

 the animals when compared ten days after the last injection of vaccine. 



"The production of antibodies in the serum, testable by agglutination and 

 complement fixation, is much less with the sensitized than with the nonsensi- 

 tized vaccine under the same conditions. Thus the estimation of these anti- 

 bodies in vitro does not show the actual degree of immunity given by the 

 former as compared with the latter." 



A bibliography of 39 references to the literature cited is appended. 



On Anaplasma-like bodies in the blood of vertebrates, Annie Poetek (Ann. 

 Trop. Med. and Par., 9 (1915), No. 4, pp. 561-568, figs. iO).— "Anaplasmata 

 may occur in healthy and in anemic vertebrate blood. The structures, also 

 called marginal points and peripheral coccus-like bodies, are probably of diverse 

 origin. It is doubtful if they are organismal in nature. Anaplasmata have 

 been found by me in warm- and cold-blooded vertebrates, wherein conditions 

 such as herpetomoniasis and anemia occurred. Some of the bodies originate 

 from the nucleus of the erythrocyte or erythroblast, under the influence of 

 hemolysis. The Anaplasma-like bodies were basophilic, apparently composed of 

 chromatin or of a substance giving a similar staining reaction, and were homo- 

 geneous in structure. They varied from 0.3 to 2 /* in diameter, often being about 

 0.5 fi. Binary and multiple forms, which might be interpreted as phases of 

 division, were seen." 



Some experimental researches on induced herpetomoniasis in birds, H. B. 

 Fantham and Annie Pobteb (Arm. Trop. Med. and Par., 9 (1915), No. 4, pp. 

 5JfS--558, pi. 1). — "Herpetomoniasis can be induced in birds, for example, 

 canaries (Serinus canariu^s), sparrows (Passer domesticus) , and martins (Cheli- 

 don urhiea), by feeding them on insects containing herpetomonads. Herpe- 

 tomonas culicis from Culex pipiens and H. jaculum from Nepa cinerea have 

 fatally infected birds when fed to them. Both flagellate and nonflagellate herpe- 

 tomonads have been found in the internal organs of the infected host. The cycle 

 of the flagellates in the avian hosts resembled morphologically that in the in- 

 sects. The disease induced may run an acute or a chronic course. In the acute 

 cases in our birds the flagellate form of the parasite was the more obvious at 

 death. In chronic cases, nonflagellate forms of the parasite vvei'e mon? nu- 

 merous. 



