VETERINARY MEDICINE. 583 



pp. 9-11). — This deals with the examination of nO patients who were Ivept con- 

 stantly under observation and examined according to Koch's directions. All 

 were infected with the human type of bacillus. The antiformin method was 

 found very useful for detecting the tubercle bacillus microscopically and for the 

 direct cultivation from the sputum. The antiformin does not affect the human 

 or bovine type (obtained from tracheal secretions of a tubercular cow) of 

 bacillus. 



Human tubercle bacilli in the milk of a vaccinated cow, A. S. Griffith 

 {Jour. Path, and Bad., 11 {1913), No. 3, pp. 323-328).— Much of this material 

 has been noted from another source (E. S. R., 26, p. 777). 



In addition it has been observed that a heifer, vaccinated against tuberculosis 

 when 4 days old with human tubercle bacilli, was discharging tubercle bacilli 

 which were virulent for guinea pigs. "A complete post-mortem examination 

 was not possible, as the heifer was killed in the open field. Nothing of an obvi- 

 ously tubei'culous nature was found in the udder or in the supramammary 

 lymphatic glands; the mucous membrane of the milk sinuses and ducts was nor- 

 mal, and the milk within them was also normal in appearance. A minute gray 

 tubercle was seen in the lungs, but otherwise they appeared perfectly normal. 

 The thoracic lymphatic glands were normal, and the liver and the spleen and the 

 serous membranes showed no sign of tuberculosis. The heifer had reacted 

 to the tuberculin test on 3 separate occasions, namely, 7, 12, and 2S months after 

 the protective inoculation." 



The danger to public health from this source is pointed out 



Tubercular antigens and antibodies, A. Calmette and L. Massol {Compt. 

 Rend. Sac. Biol. [Paris], 13 {1912), No. 26, pp. 120-122; ais. in CentM. Bakt. 

 [etc.], 1. AM., Ref., 55 {1912), No. 1, p. 2i).— Three kinds of antigens are pres- 

 ent in tuberculosis, an exobacillary antigen which goes over into the nutrient 

 medium and can be obtained from Koch's tuberculin by dialysis, and 2 endo- 

 bacillary antigens, one of which is soluble in water. With the 3 antigens 134 

 sera from tubercular subjects were examined, and in 92.49 per cent of the cases 

 complement fixation was obtained. The sera behave differently toward the 

 various nntigens so that a differentiation of the sera is possible. 



The differentiation of active and inactive tuberculosis in bovines with 

 the complement fixation, meiostag'inin, and ophthalmic reactions, S. 

 Wyschelessky {Ztsclir. Tuberkulose, 19 {1912), No. 3, pp. 209-237; abs. in 

 Internat. CentM. Gesam. Tuberkulose Forsch., 7 {1913), No. 5, p. 280). — When 

 phymatin was used as the antigen in the complement fixation test, it was found 

 practically as efficient as a solution of tubercle bacilli in lactic acid, or as an 

 emulsion of tubercle bacilli. The meiostagmin reaction gave unsatisfactory 

 results. Bovines strongly tubercular do not give the ophthalmic reaction with 

 dilute phymatin, and often show the presence of a large amount of antibodies 

 with the complement fixation method against phymatin. 



Comparative investigations of the ophthalmic, thermal, and intracuta- 

 neous tuberculin tests, the complement fixation reaction, and the cobra 

 venom hemolysis according to Calmette, with particular reference to the 

 specificity of the tuberculin test, especially the eye test, W. Assmann 

 {Verglelchende Untersuchungen ilber die Ophthalmoreaktion, thermische Tuher- 

 kulinprobe, Intrakuianrcaktion, das Komplcmentbindungsverfahren, und die 

 Eobra>gifthd)))olyse nach Calmette, mit besonderer Beriicksichtigung der Spezi- 

 fddt der Tuberkulinreaktion namentlich bet der Augcnprobe. Inaug. Diss , 

 Univ. Bern, 1910, pp. lO-'t). — Continuing previous work (E. S. R., 26, pp. 379. 

 584) the ophthalmic reaction gave better results with tubercular animals than 

 the thermal and intracutaneous reactions, showing positive in 100 per cent. The 



