176 



EXPERIMENT STATION BECORD. 



Corn is not considered a palatable food for guinea pigs, and animals receiv- 

 ing this food entirely, die. Feeding maize for a time or feeding it in connec- 

 tion with other feeds over a long period of time will cause falling out of the 

 hair and lesions in the gastro-intestinal canal and kidneys. Spoiled maize is 

 borne by guinea pigs as well as sound maize. All animals fed with maize after 

 a time showed a hypersusceptibility to maize extracts. 



In regard to the detection of erysipelas bacteria in putrefied organs and 

 in the animal body after vaccinating by the Lorenz method, W. Wagneb 

 {Vntcrsuchungen iiher den Nachweis van Rotlaufbacillen in faulen Organen 

 und im Tierkorper nach der Lorenz\schen Schutzimpfimg. Inaug. Diss Univ 

 Bern, 1910, pp. 38).— It the putrefactive process has not proceeded tw far,' 

 there is no difficulty encountered in detecting the presence of the Bacillus 

 erysipelatis in the organs of the animals affected with the disease. The B. 

 erysipelatis was found present in a viable condition 13 days after vaccination. 

 On the fourteenth day the organisms were probably destroyed because they 

 could not be noted in the blood, and after the eighteenth day' the bacteria had 

 entirely vanished from the body. According to this, if the disease develops 

 after the eighteenth day, it can not be attributed to the use of living cultures 

 for vaccination puri)oses. 



Salvarsan in the treatment of surra in horses, dogs, and rabbits, J. D. E. 

 Holmes {Mem. Dept. Agr. India, Vet. Ser., 1 (1913), No. 2, pp S9-l',8- abs in 

 Jour. Compar. Path, and Ther., 26 {1913), No. 1, p. 91). -In the first part of 

 this paper (pp. 89-107), which deals with salvarsan in the treatment of surra 

 in horses, a report is given of 17 cases treated by a single intravenous injection 

 of salvarsan, of 2 cases by 3 injections of salvarsan at one day's interval and 

 also at one week's interval, and of 4 cases by a combined treatment of salvarsan 

 and arsenious oxid. The author finds that in horses the toxic amount of 

 salvarsan injected intravenously is approximately at the rate of 0.01 gm. per 

 pound of body weight. Individual susceptibility to salvarsan exists. An 

 intravenous injection of salvarsan is followed by a disappearance of trypano- 

 somes from the circulation for periods varying from 6 to 37 days. The relation 

 between the amount of salvarsan injected and the period of absence of parasites 

 is neither regular nor definite. 



In 3 cases a cure followed a single intravenous injection. The curative 

 property of salvarsan is not in exact proportion to the amount of dru- admin- 

 istered. By repeated administration a tolerance to salvarsan is established. 

 One of 2 ponies which received 3 injections of salvarsan at intervals of one 

 day was cured. Three intravenous injections did not give results superior to 

 those following smgle injections. The administration of a large dose of 

 arsenious oxid, followed 24 hours after by an intravenous inject^ion of sal- 

 varsan, produced no better results than a single dose of either. 



The second part of this paper (pp. 109-144) relates to the salvarsan treat- 

 ment of surra in dogs; the third part (pp. 145, 146) to salvarsan treatment of 

 surra in rabbits. A list of references to the literature on the subject is 

 appended. 



The specificity of the immunity reactions with various trypanosomes, 

 H. Braun and E. Teichmann {Arch. Schiffs u. Tropen Hyg., 16 (1912), Beihcf't 

 Ji, pp. lJil-lJ,l ; abs. in Ztschr. Immunitdtsf. u. Expt. Ther., II, Ref., 5 {1912) 

 No. U, pp. 3^3, 5.)//).— Continuing previous work, in which it was found that 

 with killed dried trypanosomes obtained from mice affected with trypano- 

 somiases it was possible to prepare an active immune serum by injecting' the 

 substance into rabbits, a closer study of the specificity of this reaction was 

 made, and in this connection active and passive immunizing tests, as well as 



