VETERIITAEY MEDICINE. 879 



Protective and curative vaccination against foot-and-month disease, 

 LOEFFLEE {Molk. Ztg. [Hildesheim], 26 {1912), 'No. 5, pp. 68-70).— This is a 

 preliminary popular description of work done with an antiserum for foot-aud- 

 mouth disease. 



The Negri bodies in rabies, E. M. Watson (Jour. Expt. Med., 17 (1913), 

 No. 1, pp. 29-^i2, pis. 2). — "The Negri bodies, as the etiological agent in rabies, 

 present 2 types or phases in morphology, in growth, and in reproduction. These 

 2 phases are constantly cyclic in their development and correspond (1) to a 

 multiplicative, or schizogonous, and (2) to a reproductive, or sporogonous, life 

 cycle. 



" By the detailed study of these forms and their succeeding stages we are 

 inclined to believe that the Negri bodies are definite protozoan parasites, and 

 from a study of their life history we are led to place them in the suborder of 

 Cryptocysts, or Microsporidia, of the Sjwi'ozoa, and more definitely among the 

 Oligosporogeuea of the Glugeidie family, which forms produce but one pan- 

 sporobla.st." 



Chemotherapeutic trypanosome studies with special reference to the 

 immunity following' cure, B. T. Tekry {Monographs Rockefeller Inst. Med. Re- 

 search, 1911, No. 3, pp. 79). — "When mice infected with various species of 

 trypanosomes are given curative doses of a number of different medicaments, 

 an immunity to the species cured is usually demonstrable in the tests made 

 several days later. While the interaction of trypanosomes and some form of 

 treatment seems essential for the production of this immunity, it is not neces- 

 sary for the animals to be visibly infected. . . . The immunity is specific in 

 the sense that mice immunized to one species, show, as a rule, no resistance to 

 infection with other species. . . . Examples of a possible nonspecific immunity 

 were observed in mice immunized to surra of India and tested with mal de 

 eaderas and vice versa, and also in mice immunized to douriue and tested with 

 mal de caderas. 



" The production of immunity in mice following the cure of experimental 

 trypanosome infections seems to be a general phenomenon, for it has been 

 possible to demonstrate its presence against every strain thus far tested. The 

 immunity develops early, being detected at times between the second and third 

 day after treatment. The immunity following cure is temporary. In most 

 instances it seemed strongest 4 to 6 days after treatment. Sometimes, however, 

 it disappeared completely in S to 11 days, and in animals tested but once it was 

 unusual to find much resistance 20 days after treatment. . . . 



" In the experiments a strong immunity has been obtained with greater ease 

 against the more virulent than against the less virulent trypanosomes. The 

 infection against which it has been easiest to secure immunty was surra of 

 India. With the less virulent dourine, on the other hand, the results have been 

 much less satisfactory. Against the latter infection, 12 attempts to produce 

 an efficient immunity have thus far failed. The sti'ongest immunity was usually 

 obtained by employing one of the dyes, either alone or in combination with 

 acetyl-atoxyl. While acetyl-atoxyl is usually rapidly excreted, an injection 

 of this medicament has, in a number of instances, prolonged the excretion of 

 dichlorbenzidin plus amidonaphtoldisulphonic acid 1.8.3.6. given 4 or more days 

 afterwards. Surra of India was particularly sensitive to dichlorbenzidin em- 

 ployed alone or in combination with acetyl-atoxyl. 



" In treating mice with dichlorbenzidin a strong immunity was at times ob- 

 tained following the injection of small quantities of the medicament. In one 

 instance half the usual curative dose gave rise to a strong immunity against 

 surra of India. Additional evidence that the action of dichlorbenzidin is indi- 

 rect seems to have been furnished by the fact that rich intraperitoneal iujec- 



