370 EXPEEIMENT STATION RECORD. I Vol. 43 



{grains indicated tliat the absence of vitamins ]>r()duces important chanjios in 

 the testicles, clianicterized l»y an arrest .in tlie functioning of the gUmd and liy 

 phenomena of iu\olution wliich are confined at first to a decrease, later to a 

 complete arrest of spermatogenesis, and finally the resorption of spermatozoa 

 and spermatids. This is thought to indicate a deficit in the sterilized food 

 of a special form of nucleins. 



Total dietary regulation in the treatment of diabetes, F. M. Allkn, E. 

 Stillman, and II. Fitz (Monoy. RorkefeJIer Inst. Med. Research, 1919, No. 11, pp. 

 ^'I-{-6/f6, pis. 6'J). — This monograph constitutes one portion of a research "com- 

 posed of tlii'ee princii)al interdependent parts. One of these has compared 

 clinical diabetes in its principal characteristics witli that produced experi- 

 mentally in various species of animals, and has shown that the latter, in the 

 absence of spontaneous tendencies, is influenced by change* in the total 

 metabolism and body weight, and not ])y carbohydrate ingestion alone. The 

 second is the present clinical investigation, in whicli this principle has been 

 api)lied to patients. The third is a pathological study, not yet finishes!, but 

 included here in the form of a preliminary outline because of its important 

 relation to the problems of treatment." 



Following an introductory chapter dealing with the history of diabetes, the 

 author's plan of dietetic treatment is described at length, clinical reports are 

 given of 76 out of 100 cases of diabetes treated at the Hospital of the Rocke- 

 feller Institute by this method, and general conclusions are drawn as to the 

 etiology and pathology of the disease and the effect of various: factors upon 

 its progress. 



H\perimental studies on diabetes. — I, Production and control of diabetes 

 in the dog, F. M. Allen {.Jmir. E.rpt. Med., 31 {1020), No. -}, pp. 36S-J,02).— 

 The two papers presented are the first of tlie series comparing clinical diabetes 

 with experimental diabetes in animals which constitutes a part of the research 

 on diabetes noted above. The basis of tlie present studies has been a form of 

 diabetes produced by removal of the greater part of the pancreas of animals 

 but leaving a remnant about the duct secreting normally into the duodenum. 



(!) Gross anatomic relations of the pancreas and diabetes (pp. 363-370). — 

 In this paper are sununarized the ordinary relations between body weight and 

 pancreas weight in dogs and between the total pancreas and the size of the 

 remnant with which diabetes occurs, the results of these observations serving 

 as the working basis for succeeding experiments. 



(2) Effects of carbohydrate diets (pp. 381-402). — This paper reports that 

 the excessive carbohydrate diets of various kinds had the same effect upon 

 partially depancreatized dogs as upon human diabetic patients, resulting in 

 rapid decline and death. In the early stage glucose was more effective than 

 starch in producing diabetes. Whenever permanent diabetes was present starch 

 brought on glycosuria more slowly than did sugar but just as surely, and the 

 difference in time is thought to be due merely to the difference in the rate 

 of absorption of the carbohydi'ate. No noticeable differences were noted be- 

 tween the assimilation of different starches, nor did there appear to be any 

 marked lowering of the carbohydrate tolerance by proteins. 



Antipyretics (Arch. Int. Med., 24 (1919), No. 6, pp. 611-632, flgs. -}).— Three 

 papers are presented which deal especially with clinical investigations of the 

 respiratory exchange as influenced by antipyretic substances. 



I. The Benedict respiration chamber at the Ncio Haven Hospital, by H. G. 

 Barbour (pp. 011-616). — This paper gives a general description of the respira- 

 tion chamber at the New Haven Hospital, similar to but differing in certain 



