854 EXPERIMENT STATION RECORD. [Vol.43 



Experimental inoculation of malaria by means of Anopheles liidlowi, 



S. T. Darling (Jnur. E.rpt. Med., 32 (1920), No. 3, pp. 313-32!), pis. .?).— "Three 

 persons were experimentally inoculated with malaria by means of ,4. Ivdlowi 

 reared from larvjc and infected with a pure strain of subtertian Plasmodium 

 (Plasmodium falciparum), thus proving that there exists no mechanical im- 

 pediment or obstacle to the free exit of sporozoites from the salivary ducts or 

 proboscis. In the dissection of infected mosquitoes there were no evidences 

 of degenerated zygotes. Sporozoites appeared promptly in the salivary glands 

 (9 to 12 days). Inoculation occurred with ease either in an interrupted feed- 

 ing or after mosquitoes had been fed twice previously. The period of incuba- 

 tion was 14 and IS days. The clinical manifestations were more severe in the 

 subject that had never been infected with malaria previously, while the splenic 

 enlargement was most pronounced in the subject infected after a long interval 

 of freedom from malaria. In a third subject already suffering from tertian 

 malaria, there was only the slightest evidence of physical illness elicited by the 

 superimposed subtertian infection ; his temperature, however, became duly 

 elevated. 



" The type of febrile reaction in the two uncomplicated cases was at first ter- 

 tian, becoming quotidian later, and this phenomenon in a pure strain leads 

 strongly to the supposition that P. falciparum possesses inherently both ter- 

 tian (or subtertian) and quotidian tendencies, as well as its well-known tenden- 

 cies to cause fever of the irregularly remittent or continued type. The creation 

 of a .specific Plasmodium to account for clinical forms of sestivo-autumnal or 

 subtertian malaria having a quotidian periodicity is probably unwarranted. 



" In consideration of the facility with which this species can be infected and 

 man inoculated experimentally, the occurrence of naturally infected wild 

 specimens, and the positive epidemiological evidence, there should no longer 

 exist in the minds of sanitarians any doubt as to its being a malarial carrier. 

 Operations against this species can, therefore, be recommended without reserva- 

 tion and should be carried out without delay." 



A new species of Phyilotreta, F. H. Chittenden (Jour. Wash. Acad. Sci., 

 10 (1920), No. 13, pp. 389, 390, fig. 1).— Phyilotreta utana n. sp., has been ob- 

 served to attack sugar beet in Utah and to be abundant in a beet field over- 

 grown with hedge mustard, on which it was also taken. It is recorded as 

 occurring at Logan, Alta, and Park City, Utah ; Elko, Nev. ; and Corvallis, Oreg. 



Wood-boring beetles of black locust, O. W. Rosewaij> (Canad. Ent., 52 

 (1920), No. 9, p. 203). — A list is given of eight species of beetles reared from 

 Robinia pseudacacia at Baton Rouge, La. 



Larvae of North American beetles of the family Cleridfp, A. G. Roving 

 and A. B. Champlain (Proc. U. S. Natl. Mus., 57 (1920), pp. 575, 6-',n, pis. 12). 



The influence of chemical constitution on the toxicity of organic com- 

 pounds to wirevvorms, F. Tattersfield and A. W. R. Roberts (Jour. Agr. Sci. 

 [England], 10 (1920), No. 2, pp. 199-232).— This is a report of work at the 

 Rothamsted Experimental Station. 



" The relationship between chemical constitution and toxicity to wireworms 

 [Agriotes] of organic compounds is found to be of a twofold nature. The 

 general effect of a group of compounds of the same type is directly determined 

 by the chemical constitution of the type. The particular effects of individual 

 members of the groups are limited by their physical properties, such as 

 volatility, etc., which may be regarded as indirect consequences of their chemical 

 constitution. 



" The aromatic hydrocarbons and halids are on the whole more toxic than 

 the aliphatic hydrocarbons and halids. The groups that influence toxicity 



