VETERINAKY MEDICINE. 277 



of the parasites aud their progressive iucreuse in tlie blood. Novo-tryposafrol 

 may tlierefore be regarded as useless in the treatment of canine piroplasmosis 

 suid, judged from these results on dogs, it will no doubt prove to be equally 

 useless in the treatment of bovine piroplasmosis when it lias received a scien- 

 tific trial in competent hands. 



" In view of the negative results obtained by ourselves and other independent 

 investigators, working especially with trypanosomiasis, we conclude that the 

 value of tryposafrol or novo-tryposafrol as a remedy for any of the diseases 

 enumerated by the authors is open to grave doubt, since the chief claims as to 

 its eflicacy were based on experimental results which the authors state that 

 they obtained with nagana." 



A list of nine references relating to tryposafrol is appended. 



The tubercle bacilli content of the musculature, the blood, and the lymph 

 of apparently nontuberculous animals, M. Mtjlleb and T. Ishiwaea (Centbl. 

 Bakt. letc], 1. Abt., Orig., 74 (1914), No. 5-6, pp. 393-455, fig. J).— The authors 

 report that the dissemination of tuberculous infection in the animal's body 

 takes place chiefly by the lymphogenous route. Tubercle bacilli are not as a 

 rule demonstrable in the blood stream of animals affected with generalized 

 tuberculosis, nor are they always noted in tuberculous broncho-pneumonia with 

 foci. A tuberculous infection of the intermuscular lymph nodes does not indi- 

 cate an infection of the blood. When tubercle bacilli are present in the blood 

 or in the intermuscular lymph nodes the musculature is almost always free 

 from them. The tuberculous infection of the intermuscular lymph nodes occurs 

 as a rule in either a purely lymphogenous or hematogenous manner through the 

 agency of the nourishing blood vessel. The infection of the various organs of 

 the animal body which do not communicate directly with the outside is not 

 necessarily brought about by way of the blood stream. Some heavily tubercu- 

 lous animals harbor latent tubercle bacilli in the spleen, liver, and intermuscular 

 lymph nodes. 



Danish investigations showing' how tubercular fowls infect pigs, J. J. 

 Dunne (Trans, in Jour. Bd. Agr. [London'], 22 {1915), No. 1, pp. ^1-^5). — 

 Investigations having shown that pigs may be infected with avian tuberculosis, 

 examinations were made, at the Danish State Laboratory, of tuberculous mesen- 

 teries and tonsils taken at abattoirs of several swine-slaughtering companies. 



Examinations of the diseased organs of 118 tubercular pigs showed 86 of them 

 to contain bacteria identical in every respect with avian tubercular bacteria, 

 and 28 to contain tubercular bacteria of the bovine type. In the remaining 4 

 cases the bacteria deviated in form from both types, but in two cases closely 

 resembled the avian type. 



" The results of the foregoing examinations show that the character of the 

 disease varies in accordance with the type of tubercular bacteria by which the 

 pig is attacked. An attack of avian tubercular bacteria is usually of a local 

 character, while that of bovine tubercular bacteria is of a general character. 

 ... On the whole the results of the investigations show that the overwhelming 

 majority of the cases of mesenteric tuberculosis are of a local character and 

 almost exclusively due to avian tubercular bacteria." 



Examinations of swine on five farms at Remkolde with a total of 163 pigs, 

 where bovine tuberculosis no longer exists but where the poultry was tuber- 

 cular, gave 6, 17, 18, 21, and 36 per cent, respectively, of tubercular animals. 



In two cases where the existence of avian tuberculosis amongst the swine was 

 detected the owners disinfected the sties and the hen roosts and carefully isolated 

 the animals. The swine reared under the new conditions were found to be 

 entirely free from the disease, although prior to taking these precautions two 

 or more animals in every lot were found to be affected. " It appears, therefore, 



