182 EXPERIMENT STATION EECOED. 



to the disorder, or in other words represents a stage in the life history of the 

 specific infective agent; or, it may be, a culture form . . . The specific body 

 resembles no parasite of which the life history is so far known . . . 



" The second body described affords evidence of the existence of a second 

 specific complaint which may be and probably has been in the past confused 

 with true rinderpest. It would be important to determine if animals affected 

 by the second complaint when they have recovered are still susceptible to true 

 rinderpest. The second body also is a new form." 



About a supposed neutralization of the activity of tetanus toxin by neurin 

 or betain, V. Adsersen (Ztschr. Imminiitdtsf. u. Expt. Ther., I, Orig., 17 {1913), 

 No. 2, PI). 135-140). — Either neurin or betain hydrochlorid is capable of neutral- 

 izing tetanus toxin, but this is not due to any specific property of the two sub- 

 stances but rather to the inhibition of an acid or an alkali. If an acid or an 

 alkali is added to tetanus toxin, no toxic results are produced. 



On " tick paralysis " in sheep and man following bites of Dermacentor 

 venustus, with notes on the biolog-y of the tick, S. Hadwen (Parasitology, 

 6 {1913), No. 3, pp. 283-297, pis. 2).— '"Tick paralysis' occurs in British 

 Columbia and affects man, sheep, and probably other animals. The disease 

 is caused by the bites of D. venustus. It is usually of short duration, is benign 

 in character, but occasionally it persists for long periods, and may terminate 

 fatally. From an economic point of view the disease is of some importance to 

 the sheep industry. The causative agent has not been discovered, and the 

 disease has not been reproduced by inoculation. The most likely hypothesis 

 is that the tick injects a toxin which gives rise to symptoms appearing coin- 

 cidentally with the complete engorgement of the tick. In three consecutive cases, 

 experimentally produced by me in lambs, paralysis occurred 6 to 7 days after 

 the ticks were put on. In no case did I fail to produce paralysis through the 

 agency of the tick bites. It has been proved that D. venustus usually bites 

 sheep along the backbone; possibly the point of attachment may have some 

 bearing on the symptoms or severity of the case." 



Experimental " tick paralysis " in the dog-, S. Hadwen and G. H. F. Nut- 

 tall {ParasitUogy, 6 {1913), No. 3, pp. 298-301) .—This is a report of experi- 

 ments in which "tick paralysis" was experimentally produced in a dog at 

 Cambridge through the application of a single Dermacentor venustus female 

 from Canada. The disease is said to be the same as that observed in sheep 

 and described in the paper above noted. The examination of the dog's blood 

 proved negative. 



The chemistry of tuberculin, G. Lockemann {Hoppe-Seyler's Ztschr. 

 Physiol. Ghent:, 73 {1911), No. 5, pp. 389-397; ahs. in CentU. Bakt. [etc.'\, 1. 

 AU., Ref., 52 {1912), No. 1-2, pp. 37). — If tubercle bacilli are grown in a medium 

 containing asparagin as the only source of nitrogen, protein-like substances 

 are developed in the culture medium which are supposed to originate from the 

 tubercle bacillus ; consequently the author believes that the metabolic products 

 elaborated by the tubercle bacillus are somewhat dependent upon the make-up 

 of the medium in which they are cultivated. 



Contribution to the chemistry of the tubercle bacillus. — A preliminary 

 report, E. Lowenstein {GentU. Bakt. [etc.}, 1. AM., Orig., 68 {1913), No. 7, 

 pp. 591-593). — ^As an initial step in determining whether the composition of 

 tuberculin wag dependent upon the nutrient solution used for cultivating the 

 tubercle bacillus, an attempt was made to find a simpler nutrient solution than 

 has heretofore been used for preparing tuberculin. A nutrient solution com- 

 posed of ammonium phosphate, glycerin, and distilled water was prepared and 

 inoculated with the tubercle bacillus. Some controls received an addition of 

 0.4 per cent of either sodium chlorid, potassium chlorid, or potassium sulphate. 



