282 EXPEEIMENT STATION EECORD. 



The author has had under observation over 30 dogs which were completely- 

 immune and thoroughly refractory toward rabies. The animals received from 

 4 to 8 gm. of fixed virus intraperitoneally and these amounts were able to pro- 

 tect the animals against an infection with fixed or street virus which was given 

 14 days following the vaccination. Subcutaneous injections, when given as 

 recommended by Ferran, always produced a strong inflammation of the sub- 

 cutaneous tissue, consequently this method of injection was abandoned. A part 

 of the animals were infected either subdurally several months later, or were 

 bitten by a rabid animal, with the result that all of the animals remained 

 sound. In another series of experiments manifestations of immunity were 

 noted when immune serum was injected intravenously, subcutaneously, or intra- 

 peritoneally in animals, but when the serum was introduced into the spinal 

 canal the animals (dogs and sheep) were absolutely protected. Probably a 

 local immunity was concerned here. With this new intraspinal method 16 

 sheep, about 20 dogs, about 80 rabbits, and 1 horse were treated. 



In reg"ard to Miessner's report with, reference to immunizing animals 

 ag-ainst rabies, W. Pfeileb (Berlin. Tierdrztl. Wchnschr., 29 {1913), No. 30, 

 pp. 54O-543). — A polemic. 



Immunizing' dogs against rabies, W. Pfeiler and G. Kapfbeegee (Ztschr. 

 Tnfektionskrank. u. Hyg. Haustiere, 13 {1913), No. 6, pp. 307-316).— This is a 

 detailed statement of the results of an investigation, noted above, with experi- 

 mental data. 



In regard to immunizing against rabies, Miessnes (Berlin. Tierdrztl. 

 Wchnschr., 29 (1913), No. 31, p. 558).— A reply to the above. 



Sporotrichosis of animals, De Beubmann and Gougeeot (Rev. G4n. M6d. 

 V6t., 21 (1913), Nos. 250, pp. 557-586; 251, pp. 626-645, figs. 21).— This paper on 

 the comparative pathology of sporotrichosis takes up the subject under the 

 headings of spontaneous sporotrichosis of the rat, dog, mule, and horse ; experi- 

 mental sporotrichoses of animals; clinical diagnosis; and prognosis and treat- 

 ment. 



The trypanosomes causing dourine (mal de coit or Beschalseuche), B. 

 Blacklock and W. Yoeke (Proc. Roy. 80c. [London], 8er. B, 87 (1913), No. 

 B 593, pp. 89-96, pi. 1, figs. 3). — This is in continuation of work of which a 

 preliminary account has been previously noted (B. S. R., 27, p. 884). The 

 morphology of three strains of the trypanosome, supposedly Trypanosoma 

 equiperdum, one originating in Algiers and the other two in Germany, was 

 studied. The authors are led to conclude that the symptom-complex of the dis- 

 ease, clinically known as dourine, can be produced tjy more than one species 

 of trypanosome. They were unable to distinguish morphologically the Algerian 

 form from T. rhodesiense, T. pecaudi, T. trucei, and T. ugoAidcs. 



Studies of the piroplasmoses occurring in Algeria (Bui. Soc. Path. Exot., 

 6 (1913), Nos. 8, pp. 571-574; 9, pp. 618-623) .—The first paper (pp. 571, 572), 

 by E. Sergent, A. Lheritier, and R. Ismert, relates to equine piroplasmosis in 

 Algeria and its cure by trypanblue; the second paper (pp. 573, 574), by E. 

 Sergent and M. Beguet, reports upon the occurrence of Anaplasma marginale 

 in cattle in Algeria. An acute and very grave case of piroplasmosis in a horse 

 was observed in a region from which the disease had not previously been re- 

 ported but where bovine piroplasmosis is enzootic. This case rapidly recovered 

 following the injection of trypanblue. A number of preparations of blood from 

 cattle presenting symptoms of piroplasmosis were found to contain A. mar- 

 ginale. The third paper (pp. 618-622), by E. Sergent, A. Lh§ritier, and A. 

 Boquet, relates to the treatment of bovine piroplasmosis by trypanblue; the 

 fourth paper (pp. 622, 623), by E. Sergent and A. Lheritier, reports upon an 

 intense piroplasma infection in apparently healthy cattle. 



