284 EXPEEEMENT STATION EECOBD. 



ness can be produced is largely dependent on t±ie use of a sufficient amount of 

 protein in preparing and in testing the animals. All tlie manifestations of 

 typical hypersensitiveness to protein can be produced in guinea pigs by treat- 

 ment with aqueous extracts of tubercle bacilli. Guinea pigs can be sensitized 

 witb albumose-free tuberctdin and with old tuberculin that has been freed of 

 glycerol and made poor in Baits; and sensitization with any of these products 

 causes the animal to react to injections of the others. 



" Hypersensitiveness to tuberculin develops within 7 to 15 days after infection 

 with the Bacillus tuberculosis. Tuberculous animals can occasionally be intox- 

 icated with tuberculo-protein, developing symptoms of hypersensitiveness. The 

 passive transference of hypersensitiveness from a tuberculous man to normal 

 guinea pigs has been successfully accomplished and positive results have like- 

 wise been obtained when the serum of a sensitized animal has been injected 

 into an untreated one. The type of the reaction symptoms and the development 

 of them in an infected host after the administration of minimum doses of 

 tuberculin are likewise suggestive facts." 



The author is of the opinion that the evidence gathered justifies the inter- 

 pretation of the tuberculin reaction as a manifestation of hypersensitiveness. 



Tuberculin in diag-nosis and treatm.ent, L. Hamman and S. Wolman (New 

 York and London, 1912, pp. XIV +381, figs. 35). — This publication contains a 

 detailed description of the various tuberculin reactions utilized at the present 

 time, and discusses the scientific principles underlying the diagnostic and 

 therapeutic use of tuberculin. These topics are considered particularly from 

 the human standpoint. 



The relative value of turtle tuberculin in the treatment of tuberculosis, 

 W. J. Beattle and E. E. Myers (A\ Y. Med. Jour., 98 (1913), No. 11, pp. 503- 

 507). — ^A discussion in regard to Piorkowski's antigen, the Friedmann cure, and 

 von Ruck's vaccine. The use of Piorkowski's tuberculin for this disease in man 

 is described in detail. 



Treatment of tuberculosis with attenuated tubercle bacilli treated with 

 sodium fluorid, G. Rapfin (Arch. G&n. M6d., 203 (1913), pp. 262-278; abs. in 

 Jour. Amer. Med. Assoc, 60 (1913), No. 19, p. 1^97). — The vaccines used In 

 treating laboratory animals were made from attenuated tubercle baciUi de- 

 prived of their protective envelope by sodium fluorid. The cultures used in the 

 experiments have been cultivated since 1894, and this is the fourth report on 

 the topic. The results obtained with guinea pigs were very satisfactory. 



On a remarkable new type of protistan parasite, H. M. Woodcock and G. 

 Lapage (Quart. Jour. Micros. Sci. [Londoni, n. ser., 59 (1913), No. 235, pp. 

 431-457, pis. 2, figs. 2). — This paper describes a new type of parasitic Protista 

 which inhabits the rumen of animals, especially of the goat, to which the 

 authors have given the name Selenomastix ruminantium. 



"Apparently the only flagellates from which the organism could be derived 

 are the dinoflagellates and, apart from the transverse division, there is no indi- 

 cation of any affinity with this group. Further, the nature of the nucleus and 

 the capacity of moving by the body alone make it very doubtful if this parasite 

 is a true protozoan. /S. ruminantium differs in important respects from any 

 known bacteria. It has no affinities with schizosaccharomycetes, with Blasto- 

 cystis, nor with the spirochetes. In certain characters it shows a resemblance 

 to one or two large spirillar forms, or to certain members of the sulphur bac- 

 teria (e. g. Ophidomonas), but while its derivation is possibly to be sought in 

 this direction, it is, nevertheless, very far removed frum such forms. We may 

 have in Selenomastix an example of a proflagellate." 



The relation of lungworms of sheep to those of deer, E. Richtebs (Ztschr. 

 Infektionskrank. u. Eyg. Haustiere, IS (1913), No. 5, pp. 251-272, figs. 15; abs. 



