i-^^2 EXPERIMENT STATION RECORD. 



chetoses "606" (dioxydiamidoarsenobenzol or salvarsan) lias a much stronger 

 spirocUeticide action than has atoxyl. 



When "G06" and the spirochete virus were injected simultaneously, no 

 noticeable symptoms of the disease appeared and the spirochetes could not be 

 found in the peripheral blood. Although the virus employed killed control 

 geese in 4 days, diseased geese were cured not only when injected 48 hours 

 after being infected but also after 72 and even 96 hours, that is, even when 

 administered only a few hours before death would otherwise have taken place. 

 The disappearance of the spirochetes from the blood was observed to take place 

 in from 10 to 30 hours after the injection of " 606," depending upon the quan- 

 tity administered. No great difference was observed as regards the visible 

 action of different doses. The protective and curative power of " 608 " in this 

 affection is estimated at 50 times that of atoxyl. 



In experiments with piroplasmosis due to PiropJasnm higcmintim 7 animals 

 were employed, 3 being held as checks. The drug was found to dissolve large 

 numbers of the piroplasms in a very short time, setting endotoxin free and 

 resulting in an acute intoxication of the host. The author considers it prob- 

 able that a substance will be found which when injected simultaneously with 

 " 606 " will combine with the endotoxin and render it harmless to the host. 



The author's experiments led him to conclude that " GOG " has no therapeutic 

 value for rinderpest. 



Experiments on the treatment of animals infected, with, trypanosomes, 

 by means of atoxyl, vaccines, cold. X-rays, and leucocytic extract; enumera- 

 tive methods employed, IC. Eoss and J. G. Thomson {Proc. Roy. Soc. [Lon- 

 don], Scr. B, 83 (1911), A'O. B 563, pp. 227-23.', ; -4nn. Trop. Med. and Par., 4 

 (1911), No.. Jf, pp. Ji87-527, charts 5). — The experiments here reported are 

 thought to be the first in which the effect of drugs has been measured through 

 regular daily counts of the parasites by measured thick film methods. 



The treatment of trypanosomiasis, with especial reference to surra, R. P. 

 Steong and O. Teague {Philippine Jour. Sck, B. Med. Sci., 5 (1910), No. 1, pp. 

 21-53): — The authors here consider the more important methods of treatment 

 of trypanosomiasis under the headings of serum therapy and vaccination, and 

 treatment with anilin and other dyes, with compounds of arsenic, with com- 

 pounds of antimony, and with a combination of 2 or more drugs. Four series 

 of experiments are reported which show conclusively that monkeys (Cynomol- 

 gus philippincnsis) can be ^ui-ed permanently of surra infection by a single 

 injection of arsenopheuylglycin. 



Experiments with horses and mules in which 23 animals were employed are 

 also reported. The authors state "that arsenopheuylglycin has proved to be 

 by far the most satisfactory means of treatment of trypanosomiasis yet dis- 

 covered. . . . While the results in horses are the best that have as yet been 

 obtained, they are not nearly as encouraging as in monkeys. We have, how- 

 ever, for the first time been able to cure horses afilicted with surra, and this we 

 could never accomplish before by any other means. While it appears that we 

 can save a certain percentage of the horses infected with surra during an epi- 

 demic, we can never predict with certainty whether in a given instance we will 

 be able to cure the horse, or whether he will succumb first to the action of the 

 drug." 



A bibliography of 73 titles is appended. 



Epidemiolog'y of tuberculosis, R. Koch (Ztschr. Hyg. u. Infektionskrank., 

 67 (1910), No. 1, pp. 1-18, charts 7). — This is the last contribution of the late 

 Robert Koch, and treats of the epidemiology of human tuberculosis in various 

 parts of the world. 



