578 EXPERIMENT STATION RECORD. 



lu the iiiiiiiunity experiuieiits 2 sheep that had survived the iiifectiou of one- 

 half loop of agar culture were inoculated repeatedly at intervals of about 2 

 weeks with increased doses. "The inoculated material was from 24-hour agar 

 cultures washed off and suspended in sterile water. The inoculations were 

 made on the inside of the thigh in each case. No more serious symptoms devel- 

 oped than a slight swelling at the point Of inoculation and a slight elevation of 

 temperature." 



An appended simimary of data regarding the disease has been previously 

 noted (E. S. R., 12, p. 787). 



The application of atoxyl in veterinary medicine, Walther (Berlin. 

 Tierarztl. Wchnschr., 1908, Ko. 15, pp. 265, 266). — Clinical notes, together with a 

 statement of the results obtained, are given for a number of cases in which 

 atoxyl was used in the treatment of hemoglobinuria and pneumonia in horses. 

 Atoxyl appeared to have' very little beneficial effect in the control of hemoglo- 

 binuria but a consideral)le percentage of cases of pneumonia were beneficially 

 affected. In 2 eases, however, no effect of the atoxyl was to I)e ol)served. 



Treating rabies with atoxyl, B. Heymann (Ztschr. Hyg. u. Infektionskrank., 

 59 U90S), pp. 362-366).— Ou account of the favorable results reported by a 

 number of investigators from the use of atoxyl and other arsenical compounds 

 in treating diseases caused by trypanosomes the authpr tested atoxyl in the 

 treatment of rabies. The experimental animals were rabbits which received 

 intramuscular inoculations of fixed virus. The animals were then treated sub- 

 cutaneously or intravenously with daily doses of atoxyl ranging from 0.01 to 

 0.1 gm. No beneficial results were observed. In fact some of the animals suc- 

 cumbed sooner than would have been the case without the use of atoxyl. In 

 view of the results obtained the author believes that neither tryi)anosomes nor 

 spirilla can be considered as playing an etiological role in rabies. 



Infection and immunization of mice against rabies through the alimentary 

 tract, R. Repetto (Compt. Rend. 8oc. Biol. [Paris], 6Jf (1908), No. 15, pp. 

 776-7/8).— Previous investigators have indicated the possibility of infecting 

 and immunizing mice through the ingestion of rabies virus. The author soon 

 found in his investigations that the ingestion of rabies virus exercised a more 

 or less pronounced effect in immunizing mice against a subcutaneous inocula- 

 tion with street virus. All the rats with which the author experimented died of 

 rabies as result of feeding on rabies virus and 75 per cent of the mice were also 

 fatally infected by feeding upon virus for 1 month. After mice and rats had 

 been imfuunized by ingestion of an attenuated virus they proved to be resistant 

 to subcutaneous inoculation. In further experiments with 10 mice it was found 

 that feeding for some time upon normal nerve substance brought about a quite 

 pronounced degree of immunity to rabies. 



The'hereditary transmission of immunity to rabies, P. Remlinger [Compt. 

 Rend. Hoc. Biol. [Paris], 6't {1908), No. 7, pp. 321-323).— In order to gain fresh 

 evidence on the possibility of the transmission of immunity to rabies in ani- 

 mals the author experimented with rabbits. Experimental female rabbits were 

 immunized shortly before the period of gestation and in some cases naturally 

 immune males were used in breeding experiments. Results obtained by the 

 author indicate that immunity is never transmitted by the male, while the fe- 

 male may transmit immunity in a considerable percentage of cases. Never- 

 theless under identical conditions such transmitted immunity may be fleeting 

 and of low power. The blood of young animals which have acquired immunity 

 by hereditary process ai)pears not to have any innnunizing value. 



Biological and pathogenic properties of Sterigmatocystis lutea, Sartory 

 and JouRDE (Compt. Rend. Acad. Sci. [Paris], 11,6 (1908), No. 10, pp. 5.',8, 

 5^9). — When rabbits are inoculated in the periphei-al vein of the ear with 



