VETERINARY MEDICINE. 579 



fsfi'ri(]wntoct/sti.<i Intra, serious lesions nro proiluct'd in various parts of the 

 body. 'I'liis species of funjius appears to possess a very niarlved patboj:cenic 

 I»o\v«'r even liitrlier than that of .ts/u'/Y/fV/M.s fuuiiyatux. 



The treatment of trypanosomiases, A. Lavekan and A. TiiiBoux {Ann. Inst. 

 l'a»tciir,22 (1908), No. 2, pp. 97-13t). — A nuuii)er of arsenical preparations were 

 usihI in the treatment of guinea pigs artificially inoculated with trypanosomes, 

 chielly Tiiipanositma (/ambicnsc. A mixture of atoxyl and biniodid or bichlorid 

 of mercury produced a cure in 3 out of 12 cases. Atoxyl alone apfteared 

 to be without any pronounced effect. Arsenious acid used alone gave variable 

 results. The effect was more pronounced when the intervals between the doses 

 were short. It ai»pears to be best to administer arsenious acid by way of the 

 mouth. Trisulphid of arsenic produced a cure in G out of 13 cases when used 

 in a colloidal solution either as a hypodermic injection or administei-ed by 

 way of the mouth. 



Experimental studies on tuberculosis, E. Le\'Y, F. Blumenthal, and A. 

 Marxkk [Ciiithl. Itnkt. [Vic.]. 1. Abt., Orig., J,6 (1908), Xn. 3. pp. 27 8-2 85) .—The 

 attempt has iirevionsly been made to find more or less indifferent substances in 

 which tubercle bacilli could be gradually attenuated. The authors exi)eri- 

 mentetl with galactose, glycerin, and urea, tubercle bacilli subjected to the influ- 

 ence of these substances being tested for virulence by inoculation into guinea 



pigs- 

 It was found that tubercle bacilli are killed by maintaining them for 4 to 5 

 days in a 2."» per cent solution of galactose when added at the rate of 5 mg. of 

 l>act('ria i)er 4 cc. of the medium. After remaining 1 day in a concentration of 

 ;' mg. bacteria jier 4 cc. of an SO per cent solution of glycerin, tubercle bacilli 

 were so attenuated as not to be pathogenic for guinea pigs except in large doses. 

 In a 2.") per cent solution of urea the tubercle bacilli, when added at the rate 

 of n mg. per 4 cc. of the solution, lost their virulence completely after 2 days. 



Tuberculous infection through, the alimentary canal, M. P, Ravenel and 

 J. Reichel {Jour. Med. Ifcxcarch, J8 (1908), No. J, pp. 1-18). — In order to test 

 tl>e power of tubercle bacilli to penetrate through the walls of the alimentary 

 tract, guinea jtigs were inoculated with an emulsion of tubercle bacilli in doses 

 of 2 cc. directly into the stomach. This method of i)rocedure was adopted in 

 order to avoid infection of the cervical lymph glands. 



Tuberculous lesions were found generally distributed in various organs, and 

 in about ;jG jj^r cent of cases the tubercle bacilli reached the lungs within 24 

 hours after introduction into the stomach. While the results obtained from 

 these experiments are not considered sufficiently positive to exclude the possi- 

 bility that infection may have taken place through the blood to some extent, 

 yet the distribution of the lesions convince<l the authors that the l»acilli passed 

 throtigh the alimentary tract. 



Tuberculous infection and the diagnosis of this disease, S. Arloing and 

 I.. Tiii'.SEXoT {Cunipt. h'rnil. Aciiil. »S((. [I'dri.s], I 'i(j (1908). \<i. 11, pp. 561 

 5(;,i). — An invasion of tubercle bacilli may produce a latent infection which dis- 

 apliears without producing any lesions at the point of infection. The greater or 

 less limitation of the anatomical signs of infection depends ui)on the virulence 

 of the bacilli and the relative immunity of the animal. Since the primary 

 lesions of tuberculf)sis may be very slight, it is easy to iniderstand that an ex- 

 P<'rimental diagnosis by means of tuberculin may b«' depended upon as reliable 

 oven in the absence of readily det«'<ted [lost-mortem lesions. 



The susceptibility of mammals to tuberculin. A. Marie and M. Tiffeneau 

 icomiit. lOiiil. Sor. Itii,!. \l'nris\. i;', {lUOS), \,,. II, pp. 501, .5(LM .—New-born 

 uninials «'M(lure an extremely large dose of tuberculin administered hypodermic- 



