VETERINARY SCIENCE AND PRACTICE. 407 



investigatorf^, the majority of whom were of the opinion that tuberculosis may be 

 transmitted from animals to man. 



Tuberculosis of the dairy cow, S. Stewart {Missouri Slate Bd. Agr. lipt. 1902, 

 pp. 268—271). — A brief account of the symptoms of tuberculosis, prevalence of the 

 disease in dairies, and dangers which arise from carelessness in handling tuberculous 

 products. 



Tuberculosis as a result of inoculation, of animals -with dead tubercle 

 bacilli, X. Paxov {Dissertation, Dorpat, 1902, pp. 131, pi. 1). — An elaV:»orate review 

 of the literature of this subject is presented in connection with a bibliography. In 

 the author's experiments tubercle bacilli from human patients were used, and the 

 experimental animals were rabbits. As a result of inoculating rabbits with large 

 quantities of dead tubercle bacilli of considerable virulence it was found that tuber- 

 cles were produced in the lungs, liver, and other organs; that these formations were 

 of short duration except in cases where the toxin was introduced in sufficient quan- 

 tity to produce death. 



The intermediary body of the tubercle bacillus, J. Bordet and O. Gengou 

 {Compt. Rend. Acad. Sci. Paris, 137 {1903), No. 5, pp. 351-353). — In experiments 

 conducted by these authors it was found that when guinea pigs were inoculated with 

 living tubercle bacilli of human origin generalized tuberculosis results without the 

 formation of an intermediary body. Negative results were uniformly obtained in 

 testing the serum for this body. On the other hand, if guinea pigs are inoculated 

 hypodermically 2 or 3 times with tubercle bacilli of avian origin, an intermediary 

 body is produced in the blood of the experimental animals, and this body leads to 

 the rapid absorption of the alexin of the l)lood l)y the Ijacillus. 



The possibility of immunizing guinea pigs against tuberculosis, E. Levy 

 {Centbl. Bait. u. Par., 1. Abt., 33 {1903), No. 9, Orig., pp. 701-703).— Dur'm^ the 

 author's experiments, which have been prosecuted since 1888, it was found that an 

 80 per cent sterilized solution of glycerin was capable of destroying the virulence of 

 tubercle bacilli within 48 hours, at a temperature of 37° C. Numerous experiments 

 were made extending over several years, for the purpose of determining the effect of 

 exposure to glycerin in solutions of different strength for different periods. A guinea 

 pig was inoculated subcutaneously with an emulsion of tubercle bacilli which had 

 been kept for 6 days in glycerin, and a similar injection was made by the intraperi- 

 toneal method in another guinea jiig. After the animals had recovered completely 

 they were inoculated with 5, -i, 3, and 2 day old cultures in succession. Finally the 

 treated animals, together with 2 control guinea pigs, were inoculated with virulent 

 tubercle bacilli. Abscesses were formed at the point of inoculation on the treated 

 animals, but within a period of 4 weeks these abscesses healed entirely, while the 

 tuberculous processes developed with fatal consequences in the 2 control guinea pigs. 

 Both of the treated guinea pigs were killed and carefully examined without finding 

 a trace of tuberculosis. 



An experiment in the use of air and oxygen in checking the course of 

 tuberculosis in tuberculin-reacting cattle, V. A. Moore {Aimr. Yet. Tier., 27 

 {1903), No. 4, pp. 289-300). — During the experiment reported in this paper 19 cattle 

 were divided into 3 lots of 5, 7, and 7, respec-tively, the lot containing 5 being un- 

 treated, while the other 2 lots were intlate<l with air or oxygen in the abdominal and 

 pleural cavities. All of the animals were affected with generalized tuberculosis in 

 <lifferent degrees. A few fatalities resulted from the inflation of the i^leural cavity. 



In all cases the immediate effects of the inflation were an increased pulse and rate 

 of res])iration and occasionally a slight rise in temjierature. Duiing the first 3 

 months of treatment the animals which received oxygen thrived better than those in 

 the other 2 lots. When the treated animals were killed and examined it was found 

 that they were still affected with generalized tuberculosis, and inoculation experi- 

 ments in guinea pigs with material obtained from the tubercles showed that the 

 tubercle bacillus was still present in a virulent condition. 



