7 'J 4 EXPERIMENT STATION RECORD. 



Verification of the diagnosis of anthrax and blackleg, Tillmann {Deut. 

 Tirnirztl. U'rlnixcln:, 11 {1903), No. 11, pp- 97-100). — The author takes the position, 

 that the obUgatory ])ai'teriological verification of the diagnosis of anthrax and l)lack- 

 leg has no good scientific basis and should l)e discontinued, both on the ground of 

 being dangerous and also because it is unsatisfactory. It is recommended that such 

 verification of a clinical diagnosis be left to the discretion of the district veterina- 

 rians and similar olficials. 



The action of iodin on the virus of anthrax and blackleg, and the possibil- 

 ity of transforming either virus into vaccine by the addition of Lugol's solu- 

 tion, V. Galtier {.Tour. Med. Vet. et Zootech., 5. ser., 7 {1903), Aug., pp. 462-467).— 

 The author made a number of experiments in inoculating rabbits and guinea pigs 

 with anthrax and blackleg cultures, after these had been treated with iodin and 

 Lugol's solution. 



As a result of these experiments it was found that the addition of 2 cc. of Lugol's 

 solution to each 1 cc. of a sporulated anthrax culture at the time of inoculation was 

 sufficient to prevent an infection with anthrax in rabbits and guinea pigs and to 

 change the virus into a vaccine which produced considerable immunity in the exper- 

 imental animals. Similar results were obtained in experiments with blackleg virus. 

 This virus was rendered harmless for guinea pigs when mixed wdth large doses of 

 Lugol's solution, or when exposed for a considerable time to a small dose of iodin. 



A new method of vaccination for blackleg, Baer {Berlin. TIerdrztl. Wchnsdu:, 

 1903, No. 12, pp. 194, 195, fig. 1). — Notes are given on a needle especially designed 

 for use in vaccinating cattle against blackleg by means of the so called " Blacklegine " 

 threads. 



Report to the Minister of Education concerning investigations on foot- 

 and-mouth disease, Loffler {Berlin. TIerdrztl. Wchnsclir., 1903, No. 13, pp. 209- 

 215). — A mixture was made of immune serum and attenuated lymph, and large 

 numbers of animals were vaccinated with this mixture to test its eflicacy in check- 

 ing foot-and-mouth disease. Animals treated with this mixture were allowed to 

 reenter infected premises within from 10 days to 3 weeks after treatment. It was 

 found that the majority of animals thus treated had developed an immunity sufficient 

 to resist natural infection after a period of 3 weeks. 



In practical tests of this method it was found that vaccinated animals developed 

 an immunity while remaining in constant association with infected animals. The 

 method used ))y the author has been found effective in immunizing cattle, hogs, and 

 sheep against foot-and-mouth disease. The use of a mixture of a horse serum and 

 serum from cattle which had recovered from the disease was very effective in pro- 

 ducing immunity in healthy cattle. A number of cattle were immunized by the 

 administration of increasing doses of lymph. In numerous experiments carried out 

 by the author young pigs were found to be the most suitable animals for the con- 

 tinuous cultivation of an immunizing lymph for general use. 



The method of Baccelli applied in the treatment of cattle affected with 

 foot-and-mouth disease, I. Sacchixi ( (Tin. Vet., 26 {1903), Nos. 3, pp. I.i-IG; 5, pp. 

 25-28; 7, pp. 39-43; 9, pp. 53-57; 11, pp. 63-67; 13, j)p. 75-79; 15, pp. 89-92; 17, pp. 

 101-104) . — The author made a study of the method proposed by Baccelli, viz, intra- 

 venous inoculations with corrosive sublimate in the treatment of foot-and-mouth 

 disease in cattle. Three injections were given at intervals of 2 or 3 days, the corrosive 

 sublimate being administered intravenously in doses of 5 cgm. from a solution con- 

 taining 100 parts water, 1 part corrosive sublimate, 1 part sodium chlorid. 



During these experiments the author found that cattle could receive 9 cgm. of cor- 

 rosive sublimate without suffering any harm and that doses of 5 cgm. lowered the 

 temperature and relieved the symptoms of the disease, even where the hoofs and 

 mouth were badly affected, and in general led to a comparatively rapid recovery 

 from the disease with cicatrization of the old lesions. 



