VETERINARY SCIENCE AND PRACTICE. 927 



rule treatment is without result. The use of antiseptics as drenclies or by subcutane- 

 ous and intratraclieal injections has proved somewhat effective in certain cases. 



Infectious cerebro-spinal meningitis in horses, H. Streit {Berlin. Tierdrztl. 

 Wchmchr., 190.y, Xo. 37, pp. 577-'>S4) . — The autlior discusses the literature of this 

 ^subject in connection with a brief bibliography. The symptoms of the disease are 

 described in a number of cases which the author observed. A bacteriological exam- 

 ination showed no micro-organisms in the spleen or blood of certain cases, while a 

 few diplococci were found in 1 case. Diplococci were isolated from the fluid in the 

 subarachnoid space. These organisms were cultivated and used in inoculation experi- 

 ments on rabbits. In these experiments rabbits died within from 36 to 48 hours 

 when inoculated with I cc. of the exudate obtained from the subarachnoid space. 



Notes are given on the morphology of the micro-organism and on its behavior on 

 various culture media. The organism is pathogenic for rabbits, guinea pigs, and 

 white iriice, but not for chickens or doves. It is destroyed by subjection to a temper- 

 ature of 60° C. for 10 minutes, by treatment for 10 seconds in a 1 per cent solution of 

 corrosive sublimate, or for 3 seconds in a 2.} per cent solution of creolin. 



Primary infectious osteomyelitis in horses, Frohner and Karnbach (Monatsh. 

 Pralct. Tier., 14 {1903), No. 10, pp. 433-444, Jigs. 6).— Detailed notes are given on 

 the symptoms and pathological anatomy of this disease in 2 cases. The coffin bone 

 and cannon bone were affected most seriously by the disease. On account of the 

 infectious nature of the disease and the practical impossibility of curing it the author 

 recommends that diseased animals should be killed. In very valuable horses it is 

 believed that the foci of the disease in the affected bones may be removed with 

 success in a considerable percentage of cases. 



Glanders, F. K. Kleixe {Ztschr. ILjrj. u. Infectionslcrank., 44 {1903), No. 2, pp. 

 183-195). — The experiments recorded in this paper were carried out partly for the 

 purpose of testing the correctness of the general belief that glanders bacillus gradually 

 loses its virulence when cultivated for long periods on nutrient media. The cultures 

 which were used by the author had been kept in the laboratory for a period of sev- 

 eral years. It was found that these cultures produced infection in guinea pigs when 

 inoculated into the abdominal cavity in very minute doses. 



The conclusion is reached that the common belief that glanders bacilli lose their 

 virulence in artificial cultures is based on mixed cultures, and that agglutination tests 

 should be made to distingtiish between the glanders bacilli and other associated 

 organisms. Such tests were made by the author with the result that a number of 

 organisms were found in glanders cultures which had nothing to do with the glanders 

 bacillus. 



Detailed notes are given on the methods for obtaining specific sera which aggluti- 

 nate the glanders bacillus. During the author's experiments little success was had 

 in immunizing guinea pigs against the true glanders bacillus. The author ascribes 

 the apparent success of other investigators along this line to the use of mixed cultures. 



Glanders among the street-car horses of Cologne, Lothes {ForUchr. Vet. 

 Ilyy., 1 {1903), Nos. 7, p]>. 209-212; 8, p>p. 237-240; 9, pp. 257-263).— On account of 

 the losses suffered from glanders by the street-car companies of Cologne an investiga- 

 tion was undertaken for the purpose of devising practical means of checking the 

 outbreaks of this disease. A number of post-mortem examinations were made and 

 the pathological lesions are described in detail. 



Notes are also presented on the various forms which the disease assumes and on 

 the conditions surrounding different (outbreaks of glanders. Mallein injections were 

 used on an extended scale with good results. In one instance 105 horses were 

 injected and 14 reacted. Of these, 12 were found to exhibit pathological lesions 

 upon post-mortem examination. The losses suffered from the destruction of glander- 

 ous horses were small as compared with the losses necessitated by the continued 

 prevalence of the disease. 



