1010 EXPERIMENT STATIOX KKCORD. 



control rattle. The material uwed lor inoeiiiation wa.s exceedingly virulent. Only 

 the .^lightest febrile reaction waw oh^^rved in the innnnnized animals and 1 of the 

 contnjl animals. In the other 2 control animala a cons^iderable ri^^e of temperature 

 was noted. Detailed notes are given on other symptoms Avhich were observed dur- 

 ing the course of the experiment. All 5 animals were killed and carefully examined. 

 The results of these po.st-mortem examinations showed that all of the animals were 

 affected to some extent with tul)erculosis. 



The author believes that it is impossible to state, on the basis of experiments thus 

 far carried out, whether von Behring's method can beajiplied without harmful results 

 in all cases or not. The innnnnized animals, however, showed an almost com]»lete 

 resisting power toward injections with virulent material, and the author concludes 

 that this method must be considered as of great value and promise in the control of 

 tuberculosis in cattle. 



The cure of tuberculosis as the keystone of the pfoblem of combating 

 bovine tuberculosis, E. Hauptmann {Ztachr. Th'ierined., 7 ( IMS) , Noa. 3-4. }ip. IfJl- 

 200; 5-6, pp. 321-357). — In the author's opinion the unity of human and bovine 

 tuberculosis must be assumed as a demonstrated fact. Attention is therefore called 

 to the great importance for animal industry of securing any method of treatment 

 which can be relied upon to cure the disease in man and animals. 



A critical historical review is presented on the literature of this subject in connec- 

 tion with a bibliography of 302 titles. In this discussion the opinions of various 

 investigators regarding the possibility of curing tuberculosis in man or animals are 

 quoted, and notes are given on the formulas which have been recommended in the 

 preparation of medicines to be used for this purpose. While various preparations of 

 silver have yielded encouraging results, the author considered that iodin was more 

 promising, and in the use of various forms of this drug finally experimented with a 

 preparation recently put upon the market under the name lodipin. This remedy 

 may be used in the treatment of tuberculosis in cattle, either by hyiwdermic injec- 

 tions or by way of the mouth. 



The author made experiments on cattle during which lodipin was repeatedly 

 injected under the skin. No irritation, inflammation, or infiltration was observed. 

 The drug remains sterile and there is therefore no necessity of sterilizing the inside 

 of hj'podermic syringes after treating experimental animals. Numerous experiments 

 were also made during which cattle were fed varying quantities of lodipin. In the 

 first experiment a tuberculin reaction was obtained in animals which had been 

 treated with lodipin, but the tuberculous foci gave evidence of being gradually 

 walled in l)y connective tissue and of becoming less virulent. It was found by fur- 

 ther experiments in the subcutaneous use of lodipin that this drug could be admin- 

 istered to cattle in daily doses of 50 gm. without producing any injurious effects upon 

 the experimental animals. The largest dose which was administered was 600 gm., 

 and this had no bad effects upon the animal. In 4 tuberculous animals subjected to 

 repeated doses of lodipin no tuberculin reaction was obtained when they Avere tested 

 later, and an examination of the animals indicated that they were ai)parently cured. 



This method of treating tuberculosis in cattle is compared with the methods pro- 

 posed by Bang, von Behring, Ostertag, and others, and the advantages and disad- 

 vantages of the various methods are discussed in considerable detail. The author' 

 believes that his method possesses many advantages over all other methods, and ia' 

 to be preferred in combating tuberculosis in cattle. The author suggests that his 

 method be tested on a large scale for the i:)urpose of determming its practicability. 



Tuberculin tests in western Norway, C. Lekn.es {Norsk. Vet. Tidsskr., 16 

 (1904), No. 1, pp. 1-7). — A brief account is given of the tuberculin tests which have 

 Vjeen made during recent years in western Norway, with notes on the })revalence of 

 tuberculosis as indicated by these tests. 



The utilization of the meat of tuberculous animals m Germany, Kopp {Rev. 



