1022 EXPERIMENT STATION RECORD. 



The passage of rabies virus through filters, Rkmlingek (,I/;//. Insl. T'uxlnir, 

 17 {lHO.i), Xo. I.', I'll. S.J.'/-S49). — A iiunil)er of oxperiineiitri were c'luiicd out in inoc- 

 ulating rabbits w itli rabies virus. While the sulxlural inoculation produces rabies, 

 the subcutaneous inoculation iinnuinizes the rabbit against the disease. Experi- 

 ments were made in filtering virus, but on account of the fact that virus which had 

 been passed througli a lierkefeld filter was found to be still pathogenic, the conchi- 

 sion is drawn that the ral:)ies organism must be ultramicroscopic in size. From the 

 fact, however, tliat the use of a centrifuge separates the virus into a pc'ri])heral 

 inactive and ceTitral active portion, it is conchided that the cause of ral)i('s is a 

 (U'llnite uiganisiii and not a mere toxin. 



Rabies virus obtained from spontaneous cases of the disease and fixed 

 virus, ScHtJOEK {Ztuchr. Iliig. u. Infedionskranh., 4-- {lf>0:3), No. S, p]>. 362-388). — 

 Experiments were carried on for the purpose of determining the cause of the differ- 

 ence between these 2 forms of the virus. During the author's experiments it was 

 found that the course of spontaneous cases of rabies was from 2 to 5 days and seldom 

 exceeded (> days. The incubation period of spontaneous cases, however, varied 

 greatly. 



It is believed that the striking variation in the period of incubation in cases of 

 spontaneous rabies is due largely to the different specific properties of the samples of 

 virus ol)tained from spontaneous cases of the disease. Street virus can not be 

 assumed to have a constant virulence, as is the case with the fixed or laboratory virus. 

 Further experiments showed that the incubation period was almost the same in all 

 cases where the experimental animals were inoculated with street virus obtained 

 from the same source. 



The author believes from his studies that the lesions in the central nervous system 

 in cases of rabies are due to the toxins produced by the pathogenic organism and not 

 to the organism itself. 



Differential diagnosis of rabies by subdural inoculation of rabbits, A. N. 

 Aleksveev {Uchen. Zapiski Kazan Vet. Inst., 20 [1903), No. 5~G,2ip- 485-490) .—T\\\?. 

 method was tested in diagnosing rabies in suspected dogs brought to the laboratory. 



The first experiments consisted in the inoculation of 1 rabbit with a portion of the 

 medula oblongata and another rabl)it with an enmlsion of similar material. The first 

 rabbit died 169 days after inoculation, while the second remained alive. Further 

 experiments were made in inoculation of rabbits for the purpose of determining the 

 incubation period of rabies produced l)y the use of street virus. The author con- 

 (^ludes from his experiments that the variation in the incubation period in rabbits 

 inoculated ])y the subdural method is due largely to the different susceptibility of 

 different ral)l)its to street virus. 



The histological diagnosis of rabies, Vallee {Rcc. Mfd. Yet., 8. srr., 10 (1003), 

 No. 4, ]>!>■ 93-97). — According to the author's observations the special lesions in the 

 cerebro-spinal and sympathetic ganglia as described l)y Van Gehuchten and Nelis 

 are observed in the majority of cases. They were present in all of 42 dogs which 

 died of rabies and in 25 out of 40 rabid dogs which were killed l)efore the termina- 

 tion of the disease. The author concludes, therefore, that these histological lesions 

 may be relied upon in the diagnosis of rabies in dead animals. 



Fowl cholera {Jour. Bd. Agr. and- Finlwries \_Lond(>n'\, 10 {1903), No. 3, pp. 351- 

 354). — A short account of the symptoms and pathological anatomy of this disease. 

 Recommendations are also made concerning disinfectant methods which are best 

 suited for use in the prevention of this disease and in cleaning poultry houses after 

 outbreaks of the disease have occurred. 



The hemolysin of fowl cholera, D. Cai.amioa {('rnthl. Bald. u. Par., 1. Aid., 

 Orig., 35 {1904), No. 5, pp. 618-031). — Tiie materia! used by the author was ol)tained 

 from an infected fowl during an outbreak of the disease. For the purpose of obtain- 

 ing hemolysin, cultures were made in bouillon prepared from peptonized meat. The 



