298 EXPERIMENT STATION RECORD. 



in any case as the result of its use and no evidence was obtained that it has a curative 

 effect. 



The internal administration of formaldehyde by intravenous injection, 

 H. Lomas ( Vet. Rec, 17 {1905), No. 866, pp. 498, 499).— Formaldehyde was used in 

 intravenous injections in the treatment of 3 cases of morbus maculosus in horses. 

 In 2 of these cases the dose was 1 dr. in 20 dr. of distilled water, while in the third 

 case the same dose was given in 5 dr. of distilled water. The results were perfectly 

 satisfactory in all 3 cases, 2 of which the author did not expect to recover. 



Vaccination for swine erysipelas, Schnitki (Berlin. Tierdrztl. Wchnschr., 1905, 

 No. 10, pp. 189, 190).— During the year L904 the author vaccinated nearly 6,000 swine 

 for the purpose of protecting them against swine erysipelas. The method adopted 

 was that of simultaneous injection of serum and cultures indifferent parts of the 

 body. Nearly 4,000 of the hogs received a second injection of virus. No case of 

 swine erysipelas developed as the result of vaccination and only a few cases were 

 observed in the vaccinated herds as the result of subsequent infection. 



The histological diagnosis of rabies, F. Abba and A. Bormans (Ann. Inst. Pasteur, 

 19 (1905), No. 1, pp. 49-61, pi. 1).— The literature relating to rabies is discussed in 

 connection with a short bibliography. Particular attention is given to the statements 

 of Negri regarding the discovery of the pathogenic organism of rabies. Contrary to 

 the claims of Negri the authors found that the medulla oblongata contains as viru- 

 lent a virus as is to be found in Amnion's horn. Osmic acid was found to be per- 

 fectly reliable in the diagnosis of glanders in one-half of the cases if applied within 

 24 hours after death. 



The symptoms and prevention of experimental rabies, D. Koxradi (CentU. 

 Bakt. [etc.], 1. Abt., Orig., 38 (1905), No. 2, pp. 194-199).— In the experiments 

 reported in this paper rabbits were inoculated in the legs and face and subsequently 

 subjected to various forms of treatment. 



In general the incubation period varied between 174 and 570 days. The great 

 length of the incubation period was apparently due to the small quantity of virus 

 used in inoculation. The author concludes from his experiments that infection may 

 be prevented by local antiseptic treatment. Such local treatment must follow within 

 12 minutes if inoculation was made in the legs and within 3" minutes if the virus is 

 inoculated into the face. It appears that rabies may recur like other infectious 

 diseases. 



Antirabies serum, A. Marie (Ann. Inst. Pasteur, 19 (1905), No. 1, pp. 1-8). — It 

 has been observed that when suitable quantities of serum obtained from vaccinated 

 mammals and an emulsion of rabies virus are mixed the 2 substances neutralize each 

 other. 



The author carried out a number of experiments for the purpose of testing this 

 process more accurately and for obtaining data concerning the application of the 

 method in the treatment of rabies. It was found during these experiments that the 

 serum obtained from vaccinated animals is not active toward the virus of rabies 

 except after a long preliminary treatment, The serum of untreated mammals 

 appears not to have any power of neutralizing fixed rabies virus. There is no such 

 power to be observed even in the serum of birds, wmich are naturally immune to the 

 disease. 



The action of the neutralizing serum when obtained is specific, but in many cases 

 is confined within very narrow limits. The specific substance combines with the 

 virus of rabies. 



Infection and immunity in fowl cholera, E. Weil (Arch. Hyg., 52 (1905), No. 

 3-4, pp. 412-432). — Attention is called to the many failures which have been experi- 

 enced by different investigators in devising a successful scheme of vaccination against 

 fowl cholera. 



