FHUTIIEK STUUIES ON UREINE. 535 



quaiitity nf urino contaiiied iiiiicli more carbon tlian conld be accouutod for 

 by its kiiown coiistitiicnts, ospocially l)y iirca. 



As alrciidy iiieiitiimcd in iiiy first communication to tlie Academy and 

 in my papor read bcforo tbo. Paris International Meilical Congress, 1900, 

 subcutancous injections oi' meine produce in rabbits toxic Symptoms analo- 

 gous to tliose of uraemiii in nien. l'ixperiments carried on subsoquently bave 

 shown me tbat tbo minimal letlial dose for a fnll grown rabbit is 2 cub. 

 centim. Wlien we ronsider tliat tlio average liuman l)eing éliminâtes witbin 

 24 lionrs a qnantity оГ moine snflicient to kill at least 12 fuU grown rab- 

 bits nnder Symptoms corresponding witli thosc of uraemia, there сап cxisi 

 no ralid reaso)i, wluj thc rétention of ureine hy the sifstem should not he ihe 

 cause of iiracmic intoxication . Tliis appcars even more prol)able, when we 

 ronsider tbat sonie organic poisons, f. i. toxius, lose by manii)ulation a part 

 of tlieir toxicity; it can liardly be expected tliat ureine, wbicb Iiad been 

 sul)jected to clianges of température of 0° С — 50° С, sbould still retain 

 its füll toxic power. 



As regards tlic transformation of urea into Ammonium Carbonate dur- 

 ing the alkaline fermentation of tlie urine, I bave made the following addi- 

 tional tests to prove tliat thc ui'eine is indispensable for tins transformation 

 of urea: 



1) I made a solution of pure urea in water and to this I added some 

 albumin and some ('hloride of Sodium; al thc end of several fveeks thc urea 

 still rcmaincd itnchanged. 



2) I evaporated 50 cbcm. of urine to a semi-solid, jellylike consistency 

 and treated the residue with absolute alcohol, so as to remove ail ureine 

 and urea. Now I dissolved tlie residue in water and added to it pure urea 

 and some albumin; at the end of several weeks I evaporated the liquid, 

 treated tlie residue with absolute alcohol and thiis obtained the same amount 

 of urea, wliich I liad used originally. 



3) I dissolved urea -♦- uroine in water and to this I added some al- 

 bumin and sait; at the end of onc week the solution was alkaline and con- 

 taincd no more urea. 



Before coucluding this paper I should like to refer to the présence of 

 ureine in the urine of persons suffering from diabètes tueUitus. AU textbooks 

 on pathology and physiology speak of great and even enormous quantities 

 of urea in the urine of diabetics. I can say without hésitation tliat such 

 Statements are erroneous. 



1 bave analyzed five diabetic urins with the following approximative 

 results: 



фцз.-Мат. стр. 137. y 



