1088 EXPERIMENT STATION RECORD. 



inoculation with tubori-le ])acillus, while in tho other series the guinea 

 pigs were inoculated during pregnancy. The results ol)tained may bo 

 summarized as follows: 



Guinea pigs which became pregnant during the process of tubercu- 

 losis, aborted in only a few cases. In the placenta and foetus of guinea 

 pigs which were killed on the sixteenth day of pregnancy, tubercle 

 spores and bacilli were found in various lesions. From the location 

 of these lesions it would appear that the tubercle liacillus made its way 

 throuo-h the placenta from the blood of the mother and was enabled to 

 establish itself in the tissue of the fa?tus only after the lesions had 

 been produced by the circulating tuberculin of maternal origin. In 

 the young of tuberculous guinea pigs, pathological lesions were found 

 rather abundantly, especially in the liver. The young animals soon 

 became emaciated and died ultimately of tuberculosis. A bibliography 

 of the subject is appended to the article. 



Experimental tubercular mammitis in cows and goats during 

 lactation, E. Xocard {Rcc. Jlcd. Vet., Paris, S. scv., 7 {1900), Xo. J J, 

 P2?. 721-727). — It had already been determined that inoculation of 

 anthrax cultures into the milk sinus produces death within a few days 

 and that a similar inoculation in animals which had been previously 

 vaccinated against anthrax did not produce the disease in such animals; 

 but it was observed that the anthrax bacillus persisted indefinitely in 

 the milk ducts in a virulent form, and that ultimately the animal suc- 

 cumbed to toxins produced by these bacilli. The author had, therefore, 

 already established tho possibility of the persistence and nuiltiplication 

 of bacilli in the secretions of an animal which was perfectly inununized 

 against the Imcillus. The absence of an antitoxic power of an immun- 

 ized organism was also noted. In the experiments with the tubercle 

 bacillus, the author made use of a cow and a goat in the period of lac- 

 tation. For producing inoculation it was found sutticient to inject a 

 small quantity of a virulent culture of the tubercle bacillus in such a 

 manner as not to produce any lesion of the mucous membrane. A 

 tubercular mammitis of rapid course was produced and death resulted 

 within a few weeks. A study of these cases, however, demonstrated 

 that death was the result of intoxication, not of a generalization of 

 tuberculosis. A high temperature was shown in both the cow and goat, 

 being from 40 to 41'^ C. in the former and 40 to 42^ in the latter. 



The author concludes from his experiments that the active mammary 

 gland is the most favorable of all living tissues as a culture medium 

 for tubercle bacillus and that for studying tubercular intoxication it is 

 sufficient to make inoculations into the teat of an active mammary 

 gland. 



The diagnosis of anthrax and the destruction of anthrax 

 carcasses, Mkykr (/>.v7//^ Thhi-niK-il . Wc]ii\sc]n'... 1000, No. .^0, pp. 

 570-582). — In a series of observations on Ihe reliability of variou!^ 



