VETERINARY SCIENCE AND PRACTICE. 1091 



The glanders bacillus and glanders tubercle, (x. Mayek ( Centbl. 

 BaU. a. Par., J. Ahf., i^S {1!H)U), A'<>. ';iO. pp. G'l .1-683 , pJ. i).— The 

 author presents a critical historical review of the literature relating to 

 the structure of the glanders bacillus and the tubercles formed by its 

 action. During his experiments pure cultures of glanders bacillus 

 were injected into the body cavity of guinea pigs. It was found that 

 the floating portion of such cultures could not be relied upon to pro- 

 duce acute cases of glanders. In order to accomplish this it was nec- 

 essary to emploj^ cultures from agar bouillon, rubbed up in a mortar 

 with sterile l>uttor. After inoculation with material prepared in this 

 way death occurred within from 18 to 42 hours in the case of the most 

 virulent cultures and after from 4 to 11 days in the case of less viru- 

 lent cultures. In isolated specimens of the glanders bacillus, club- 

 shaped swellings were observed at either end. In clusters of the 

 bacillus chit) forms were more abundant on rods which occupied a 

 peripheral ])osition. The general appearance and the behavior of the 

 bacillus were the same as in the case of streptothrix. The glanders 

 bacillus was ()l>served to penetrate into the lymphatic vessels and 

 mesenteries. After escaping from the body cavity the bacilli made 

 their way at once into the lymph i-avities. In some animals an exten- 

 sive accumulation of wandering cells was observed in the spleen. 

 Tubercle-s produced by the glanders bacillus were characterized by the 

 rapid accunmiation of such cells, which soon became very similar to 

 epithelial cells. After the formation of such tubercles the tissue is 

 rapidly hi'oken down l)y the action of the glanders toxin. 



Experimental aspergillosis, T. A. Rothwell {Jour. Pufh. and 

 Bact.^ 7 {lOOO), AV;. /,y>^>. 3Jf.~f)?i^'pl. l^fign. Jf).- — Intraperitoneal, subcuta- 

 neous, and dermic inoculations of Aspergillus ?iiger and A. fxni/gatus 

 were made by the author in guinea pigs and rabbits. The detailed results 

 of these experiments were ta))ulated for the purpose of comparison. 

 The majority of experiments were made by means of intraperitoneal 

 injections, this method being considered preferable to intravenous 

 injections on account of the possibility of producing em])olism by the 

 latter method. The results of such inoculations consisted essentially 

 in the formation of tubercles of various sizes in different organs. The 

 tubercles consisted in the proliferation of the connective tissue cells 

 which ultimately gave rise to small translucent bodies. During the 

 later stages of development of these tubercles, there was a noticeable 

 infiltration of polynuclear leucocytes. Both species of Aspergillus 

 were found to be capable of producing lesions which resembled one 

 anothei', l>ut injections oi A. funrk/atus caused death while those of 

 A. nlgcr did not. Both organisms were shown to l)e capable of germi- 

 nating in the living tissues. A. fuinUjatus is considered more patho- 

 genic than ^1. niger. 



