26 OLOV LINDBERG et al. 



chondrial oxidative phosphorylation system, with the flavoenzyme com- 

 ponent of the respiratory chain as the probable site of action. The relation 

 of this effect to those established in previous literature, such as loss of 

 respiratory control, release of bound DPN, enhanced swelling of the mito- 

 chondrial structure, and general uncoupling of phosphorylation from 

 respiration, remains for the moment unclear. It is tempting to speculate, 

 however, that, since the latter effects are all time-dependent whereas those 

 described in the present paper are instantaneous, there might exist a 

 cause-effect relationship between them. 



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