A. FESSARD ET TH. SZABO 373 



It is unthinkable to nic that in the simpler animal one would get more enduring 

 ertects ot activity than m the more complex animals. I remind you also that the 

 spontaneous rhythms ni the membrane potential or peripheral nerves fit the same 

 story. Both in nerves and in spontaneous beat of trog brain neurones a chemical 

 control to balance the potassium and sodium seems to me to fit in very nicely. 



EccLEs: About Dr Luco's suggestion that we take post-denervation sensitization 

 into account. That would tend to make the disused line more effective than it used 

 to be and so would work against our results on the depression induced by disuse. 

 Furthermore, we have already controlled this kind of effect in the experiment 

 where we were recording intracellularly the synaptic potentials of the nerve cell 

 and firing at it from two different paths, one disused, the other normal. 



Luco : The sensitization is normally increased when the membrane is denervated ; 

 the point is that another, different nerve is responsible for this return of sensitivity. 



