48 INTRODUCTION TO IMMUNOCHEMICAL SPECIFICITY 



TABLE 3-5 



Calculated Contribution to the Free Fnerg>- of Combination of Glucoses in 

 Reactive Groups of Dextran" 



Contribution to 

 Number of glucose units binding energy, % 



5 98 



4 95 



3 90 



2 60 



1 (terminal unit) 39 



- Kabat, 1957. 



Kabat (1957). It will be seen that the terminal glucose contributes 

 as much as 39 per cent of the total binding energy. The first five units 

 together contribute 98 per cent of the binding energy, leaving only 

 2 per cent to be contributed by the sixth glucose residue. 



These calculations give us a fairly good idea of the size of the 

 antigenic determinant in a typical carbohydrate antigen. We shall 

 see later how this information can be applied to practice. 



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