98 INTRODUCTION TO IMMUNOCHEMICAL SPECIFICITY 



TABLE 7-6 



Inhibition of Anti-D by 0.2M Solutions of Various Sugars'* 



» Numbers indicate strength of agglutination, from 4 = complete agglutination, 

 to = no agglutination. The numbers in parentheses after the names of sugars 

 indicate the group of the sugar in Makela's (1957) classification (see Figs. 6-4 

 and 6-5). 



The results suggest that the D receptor may contain a sugar of 

 group 4 as terminal unit. They are supported by the observation 

 that streptomycin, a natural glycoside of A''-methyl-L-glucosamine, 

 and rutinose [6-0-(/3-L-rhamnosyl)-D-glucose] also inhibit (Table 

 7-7). Streptomycin does not inhibit much better than L-mannose or 



TABLE 7-7 

 Inhibition of Anti-D by Glycosides 



L-glucose. This is not surprising considering that the next-to-terminal 

 unit is 5-deoxy-3-formyl-L-lyxose, which one would not expect to 

 find in red cells (Fig. 7-10), though such preconceived notions may 

 be dangerous. Rutinose, however, on a molar basis (the solution 

 available was only 0.14 as strong as the other sugar solutions studied), 

 inhibits better than streptomycin or L-mannose, which might suggest 



