THE INTERPHASE NUCLEUS 



Jacobj's procedure has been followed by a number of other workers. 

 Several of these, however, have found that their modes of nuclear 

 volume were not related in the ratios of powers of 2 (Wermel and 



IB 



e n 



10 



I 15 



I 



13 



12 



11. 



■ — i^!— 



J . 



001 0O5 0-1 0-2 0-5 1 2 6 10 20 30 W 50 60 70 80 SO 95 98 



Cumulative percentages 



Figure 2i Nuclear diameter of uninucleate cells in normal 



rat liver, plotted on probability paper as in Figure 2o. Data 



taken from Beams and King.^^^ The sigmoidal curve indicates 



a bimodal distribution. 



0-01 O-OSOIOi OS 1 2 



10 20 30 ¥050 60 70 80 90 35 

 Cumulative percentages 



38 33 338333 33-33 



Figure 22 Nuclear diameter in the normal mouse liver plotted as in Figure 20 



from the data of (A) Voss^"; (B) Jacobj"^; (C) Heiberg^""; and (D) Muller^o^. 



No well marked modes can be recognized. 



ScHERSCHULSKAjA^®^) . Furthermore, no discontinuities in nuclear size 

 were found by Lewis (W. H.)2o* in either mouse fibroblasts in tissue 

 cultures, or in a rat sarcoma. 



59 



