COMPLETE CURE OF NATURAL EPILEPSY OF DOGS 

 BY A-HYDROXY-/-AMINOBUTYR1C ACID 

 INTRODUCED INTO THEIR VENTRICLES 



Takashi Hayashi* and Kazuo NACAif 



* Department of Physiology, School of Medicine, Keio University, Tokyo, and 



t Department of Physiology, School of Dental Surgery, 

 Nihon University, Tokyo 



MEDICATION PER OS TO HUMAN EPILEPTICS 



The lethal dose of /S-hydroxy-y-aminobutyric acid (GABOB) in mice was 

 found to be 13 mg/g. Small doses were tried on human adults, but medication 

 per OS of 6 g/day (2-0 g/day) caused no change in subjective as well as 

 objective observations. 



A clinic in a certain medical school in Tokyo examined 70 epileptic patients 

 and treated them with GABOB. The results of a 12 months' study follow. 



Table 1. Case description of a treatment of an epileptic dog with 

 GABOB introduced into the cerebrospinal fluid 



Day Hour Minute 



DogB, wt. = 82 kg. Idiopathic epilepsy 



13 

 15 



24 

 13 

 20 



24 



13 



24 



00 



21 



00 

 00 

 18 



00 



00 

 00 



Cisternal injection of 1 ml of 0-2 m GABOB 



A generalized seizure occurred, and recurrently 



continued for 2 hr 31 min 

 No seizure 



Second cisternal injection of 1 ml of 0-2 m GABOB 

 A generalized seizure occurred and recurrently 



continued for 50 min 

 No seizure 



No seizure 

 No seizure 



After 1 month 

 After 2 months 

 After 3 months 

 After 4 months 



5 attacks 

 No seizure 

 No seizure 

 No seizure 



389 



