COMPLETE CURE OF NATURAL EPILEPSY OF DOGS 



391 



dogs among them since the dealers do not by choice keep such dogs and if one 

 happens to have a fit, the dog will be destroyed. 



On one occasion we told a dealer that we wanted epileptic dogs for the 

 physiological study of epilepsy and were told that there are many owners of 

 dogs which have fits lasting over several years. We listed the names of the 

 owners and called on them one by one and learned that the dogs were very 

 valuable ornamental ones of noble pedigree, sometimes very highly priced, 

 for example, one million yen or over. A partial list of 39 epileptic dogs shows 

 that 17 had 1-5 attacks per month, 7 had 6-15, 9 had 16-50, and 6 dogs had 

 over 30 attacks during a month. 



We were able to collect over 60 epileptic dogs. A few of them were treated 

 with GABOB/jer os 0- 5-2-0 g/day. The results were exactly the same as those 

 obtained with human epileptics. The principal result was that the continuous 

 appUcation of the drug could depress the attacks but if the drug was discon- 

 tinued the attacks occurred again. 



DIRECT APPLICATION OF GABOB INTO THE BRAIN 

 OF EPILEPTIC DOGS 



The 39 dogs mentioned above could be divided according to their symptoms 

 into 9 dogs with idiopathic epilepsy and 27 with symptomatic epilepsy. A dose 

 of 1-0 ml 0-2 M GABOB was introduced into the ventricle or cysterna 

 cerebellomeduUaris of these dogs. A case history is given in Table 1. Other 

 cases are shown in Table 2. Each injection of GABOB precipitated several 



Table 2. Injection of GABOB into dog cerebrospinal fluid and the 



PRECIPITATION OF SEIZURES 



seizures in 36-8% of the dogs. This had never been observed in normal dogs 

 after the injection of GABOB. The meaning of these induced seizures will be 

 discussed in a later section. The results of these injections as given in Tables 

 2 and 3 were remarkable. In several cases, complete cure resulted. This means 

 that the dogs had no attacks since the last injection of GABOB in the case of 

 the longest observation over 5 years and in the case of the shortest period of 

 observation for 6 months. The first dog treated is still alive after 5 years and 



