CONTENTS 



Chapter Page 



Genetical Analysis of the Four Haplophases 

 from a Transformed Triply Heterozy- 

 gous Ascus 26-26 



Backcross to Fermenter G ME MA 26-27 



Proof that the Multiple Factor Hypothesis 



Cannot Explain the Irregular Ratios . . . 26-28 

 The Significance of Conversion in the Long- 

 Term Adaptation to Galactose by 



Saccharomyces 26-32 



Evidence for Mutation of g to G 26-33 



High g to G Mutation Rate Among the 



Descendents of gg Parents 26-34 



Non-Mendelian Segregations 26-35 



Hybrids of g By gs Clones 26-35 



Evidence in Weil-Marked Hybrids that Con- 

 versions Occur in the Heterozygote . . . 26-39 



27 Examples of Apparent Cytoplasmic Inheritance . 27-1 



Heterosis and "Running Out" of Hybrid 



Vigor 27-2 



The Effect of Nuclear Division without Cyto- 

 plasmic Division 27-4 



Adaptation without Detectable Change of 



Genome 27-6 



Haplophase Variability vs. Diplophase 



Stability 27-8 



The Plasmagene Hypothesis 27-9 



A. The Paracrinkle Virus 27-9 



B. The Kappa Substance 27-11 



C. Antigenic Plasmagenes in Parameci- 



um 27-12 



D. Adaptive Enzyme Formation 27-12 



Gene -Dosage and Gene -Product 27-15 



Dauermodifikationen and Depletion Muta- 

 tions 27-15 



"Nongenic" Modifications 27-15 



Cytogenes 27-16 



Haplophase Variability and Diplophase 

 Stability in terms of the Plasmagene 

 Hypothesis 27-17 



28 The Bearing of the Data from Yea^t Genetics 



on the Current Concept of the Gene 28-1 



Gene -to-Gene Transfer of Gene Component. 28-4 



The Tripartite Nature of the Gene 28-4 



Degradation of the Gene 28-4 



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