CONTENTS 



Preface "^ii 



Acknowledgments ix 



FoRE^voRD xi 



Translation of the Foreword xiii 



Llst of Illustrations xxv 



Chapter I 

 INTRODUCTION 



Basic Experiments i 



Phenomenon of Local Skin Reactivity to Bacterial Filtrates; 

 Early Observations on Routes of Injection; Early Observations 

 on Specificity of the Phenomenon of Local Skin Reactivity to 

 Bacterial Filtrates; Early Observations on Time Recjuired for 

 Elicitation of State of Reacti\ity and on its Dination. 



Terminology 8 



General Considerations Concerning the Phenomenon 9 



The QuANTiTATnE Estimations of Potency of Active Prin- 

 ciples 23 



Method i: Reciprocal Titrations of Various Skin-Preparatory 

 Doses against Various Reacting Doses; Method 11: Titrations 

 of Skin-Preparatory Factors against Constant Intravenous 

 Doses; Method in: Titration of Reacting Factors against Con- 

 stant Skin-Preparatory Doses. 

 Recapitulation 28 



Chajjier II 



PHENOMENON OF LOCAL SKIN REACTIVITY TO 

 VARIOUS MICROORGANISMS 



Active Principles of Meningococcus 31 



Meningococcus "Agar Washings'" Culture Filtrates. 



Active Principles of Gonococcus 34 



Active Principles of B. Typhosus 35 



B. typhosus "Agar W^ashings" Filtrates. 



Active Principles of B. PARArvpHosus 37 



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