XXll CONTENTS 



Ei I I'd oi In iR.WKN'oi s iNjKcrioN OK An ri(;KN-|-AN IIIU)1)^ Cioxi- 

 PLF.XKS Upon Skin Sn i.s I isikh vvnii Horsk Sk.rum in Rahui is 

 Sensitized to Horse Serum 2H8 



Effect OF Bacterial Fieiraiks Injecied In iravasculari.^ LJi'on 

 Skin Sites Tesied wmi Horse Serim in RAniiirs Senshi/ed 

 WITH Horse Serum 289 



Effect of In Vivo Interachon of Anikjens wifh Antibodies 

 Upon Skin Sites Infected with B. C. G 289 



Recapitui.ation 290 



Chaj)ley X 



NATURE OF THE ACTIVE PRINCIPLES OF THE 

 PHENOMENON OF LOCAL TISSUE REACTIVITY 



Summary of Methods Used in the Production of the Phenom- 

 enon 294 



Relation of Active Principles of the Phenomenon to Exo- 

 toxins 294 



Relation of the Active Principles of the Phenomenon to 

 Endotoxins ^^10 



Relation of the Phenomenon-producing Potency to Lethal 

 Effect of Culture Filtrates 311 



Relation of the Active Principles of the Phenomenon to 

 Anaphylatoxins 319 



Relation of the Active Principles of the Phenomenon to 



FORSSMAN ANTIGEN-)-ANril50DY COMBINATION AND NoRMAL 



Toxicirv OF Serum 324 



Recapitulation 327 



Chapter XI 



IMMUNOLOGICAL RELATIONSHIPS OF THE 

 PHENOMENON OF LOCAL TISSUE REACTIVITY 



The Relation of the Phenomenon to Anaphylaxis 329 



The Relation of Toxin Hvpersusceptibility to the Phenom- 

 enon 347 



The Relation of Spontaneous Bacterial Hypersensitiveness 



TO THE Phenomenon 348 



Considerafions on the Mec:hanism and Nafure of the Phe- 



NC^MENON 34() 



Recapitulaiion 352 



