CONTENTS XXIU 



Chajjlcr XII 



IMMUNOLOGICAL, PATHOLOGICAL, AND CLINICAL 



SIGNIFICANCE OF THE PHENOMENON OF 



LOCAL TISSUE REACTR ITY 



The Relation of the Phenomenon to Bacterial Allergy .... 354 

 Focal Reactions of Bacterial Allergy in Relation to the Phe- 

 nomenon; Local Reactions of Bacterial Allergy in Relation to 

 the Phenomenon. 



The Possible Relation of the Active Principles of the Phe- 

 nomenon TO the Arthus Phenomenon in Man 366 



Toxic Manifestations in the Course of Typhoid Fever in 

 Their Relation to the Phenomenon 360 



Neutralizing Potency of Sera from Meningococcus Infec- 

 tions 371 



Neutralizing Potency of Sera from Gonococcus Infections 372 



Neutralizing Potency of Sera from Typhoid Infections 375 



Relation of the Phenomenon to Hemorrhagic Diathesis .... 376 



Effect of the Phenomenon Upon Evolution of Local Infec- 

 tions 387 



The Relation of the Phenomenon to Mixed and Secondary 

 Infections 388 



Recapitulation 390 



Chapter XIII 



APPLICATION OF THE PHENOMENON OF LOCAL SKIN 



REACTIVITY TO TREATMENT OF CERTAIN 



HUMAN CONDITIONS 



Introduction 393 



Studies on the Phenomenon-Neutralizing Antibodies of Anti- 

 Meningococcus Immune Sera and Their Use in Cases of 



Meningococcus Meningitis 395 



Studies on Phenomenon-Neutralizing Anti-Typhoid Horse 



Sera and Their Use in Typhoid Fever Patients 405 



Previous Observations on Therapeutic Effect of Anti-typhoid 

 Sera; Prejiaration of Phenomenon-neutralizing Anti-t\ j)hoid 

 Horse Sera; Clinical Observations with Phenomenon-neiuraliz- 

 ing Anti-typhoid Horse Serum: Effect upon toxemia; effect 

 upon duration of disease; temperature effect; serum sickness; 



